|A research agenda for malaria eradication: basic science and enabling technologies.
|Year of Publication
|malERA Consultative Group on Basic Science and Enabling Technologies
|2011 Jan 25
|Animals, Antimalarials, Biomedical Technology, Culicidae, Drug Resistance, Host-Parasite Interactions, Humans, Insect Vectors, Interdisciplinary Communication, Liver, Malaria, Metabolomics, Models, Animal, Models, Biological, Mosquito Control, Mutagenesis, Parasitemia, Parasitology, Plasmodium, Primates, Research, Tissue Culture Techniques, Translational Medical Research
Today's malaria control efforts are limited by our incomplete understanding of the biology of Plasmodium and of the complex relationships between human populations and the multiple species of mosquito and parasite. Research priorities include the development of in vitro culture systems for the complete life cycle of P. falciparum and P. vivax and the development of an appropriate liver culture system to study hepatic stages. In addition, genetic technologies for the manipulation of Plasmodium need to be improved, the entire parasite metabolome needs to be characterized to identify new druggable targets, and improved information systems for monitoring the changes in epidemiology, pathology, and host-parasite-vector interactions as a result of intensified control need to be established to bridge the gap between bench, preclinical, clinical, and population-based sciences.
|PubMed Central ID
| / / Wellcome Trust / United Kingdom
G0501670 / / Medical Research Council / United Kingdom
Submitted by jom4013 on December 3, 2020 - 4:15pm