A research agenda for malaria eradication: basic science and enabling technologies.

TitleA research agenda for malaria eradication: basic science and enabling technologies.
Publication TypeJournal Article
Year of Publication2011
Corporate AuthorsmalERA Consultative Group on Basic Science and Enabling Technologies
JournalPLoS Med
Date Published2011 Jan 25
KeywordsAnimals, Antimalarials, Biomedical Technology, Culicidae, Drug Resistance, Host-Parasite Interactions, Humans, Insect Vectors, Interdisciplinary Communication, Liver, Malaria, Metabolomics, Models, Animal, Models, Biological, Mosquito Control, Mutagenesis, Parasitemia, Parasitology, Plasmodium, Primates, Research, Tissue Culture Techniques, Translational Medical Research

Today's malaria control efforts are limited by our incomplete understanding of the biology of Plasmodium and of the complex relationships between human populations and the multiple species of mosquito and parasite. Research priorities include the development of in vitro culture systems for the complete life cycle of P. falciparum and P. vivax and the development of an appropriate liver culture system to study hepatic stages. In addition, genetic technologies for the manipulation of Plasmodium need to be improved, the entire parasite metabolome needs to be characterized to identify new druggable targets, and improved information systems for monitoring the changes in epidemiology, pathology, and host-parasite-vector interactions as a result of intensified control need to be established to bridge the gap between bench, preclinical, clinical, and population-based sciences.

Alternate JournalPLoS Med
PubMed ID21311584
PubMed Central IDPMC3026698
Grant List / / Wellcome Trust / United Kingdom
G0501670 / / Medical Research Council / United Kingdom

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