|Title||Regulation of the Mycobacterium tuberculosis PE/PPE genes.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Voskuil MI, Schnappinger D, Rutherford R, Liu Y, Schoolnik GK|
|Keywords||Antigenic Variation, Antigens, Bacterial, Bacterial Proteins, DNA, Bacterial, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Genes, Bacterial, In Vitro Techniques, Mycobacterium tuberculosis, Oligonucleotide Array Sequence Analysis|
The genome of Mycobacterium tuberculosis encodes approximately 170 members of the unique mycobacterial PE and PPE gene families. Evidence suggests members of these families are surface-associated cell wall proteins that may provide a diverse antigenic profile and affect immunity. To determine if the expression patterns of PE/PPE genes are consistent with a role in antigenic variability, we analyzed microarray data from 132 experimental conditions for expression of PE/PPE genes. Whole genome expression patterns show that the PE/PPE genes are regulated in a variable and largely independent manner. Gene expression profiling of 15 unique conditions identified differential regulation of 128 of the 169 PE/PPE genes. Expression of the PE/PPE genes appears to be controlled by a variety of independent mechanisms. These data indicate that differential expression of the PE/PPE genes has the potential to provide a dynamic antigenic profile during the course of changing microenvironments within the host.
|Alternate Journal||Tuberculosis (Edinb)|
|Grant List||AI 44826 / AI / NIAID NIH HHS / United States|