Regulation of the adaptive immune system by innate lymphoid cells.

TitleRegulation of the adaptive immune system by innate lymphoid cells.
Publication TypeJournal Article
Year of Publication2014
AuthorsHepworth MR, Sonnenberg GF
JournalCurr Opin Immunol
Date Published2014 Apr
KeywordsAdaptive Immunity, Animals, Humans, Immunity, Innate, Lymphocytes, Lymphoid Tissue

Innate lymphoid cells (ILCs) are a group of lymphocytes that promote rapid cytokine-dependent innate immunity, inflammation and tissue repair. In addition, a growing body of evidence suggests ILCs can influence adaptive immune cell responses. During fetal development a subset of ILCs orchestrate the generation and maturation of secondary lymphoid tissues. Following birth, ILCs continue to modulate adaptive immune cell responses indirectly through interactions with stromal cells in lymphoid tissues and epithelial cells at barrier surfaces. In this review we summarize the current understanding of how ILCs modulate the magnitude and quality of adaptive immune cell responses, and in particular focus on recent evidence suggesting that ILCs can also directly regulate CD4(+) T cells. Further, we discuss the implications that these pathways may have on human health and disease.

Alternate JournalCurr. Opin. Immunol.
PubMed ID24594491
PubMed Central IDPMC3979357
Grant ListDP5 OD012116 / OD / NIH HHS / United States
DP5OD012116 / OD / NIH HHS / United States
P30DK50306 / DK / NIDDK NIH HHS / United States

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