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Recent advances in understanding dendritic cell development, classification, and phenotype.

TitleRecent advances in understanding dendritic cell development, classification, and phenotype.
Publication TypeJournal Article
Year of Publication2018
AuthorsSchlitzer A, Zhang W, Song M, Ma X
JournalF1000Res
Volume7
Date Published2018
ISSN2046-1402
KeywordsAdaptive Immunity, Animals, Dendritic Cells, Humans, Phenotype, Self Tolerance, Tumor Microenvironment
Abstract

Dendritic cells (DCs) play an essential role in the induction of adaptive immune responses against infectious agents and in the generation of tolerance to self-antigens. In this mini-review, we summarize new evidence suggesting that the tissue of residence significantly shapes the last developmental steps of DCs into locally adapted cellular entities, enabling them to perform tissue-specific tasks while maintaining the core DC properties. We also discuss recent advances that have highlighted DCs' rather complex phenotypic and functional heterogeneity in the tumor microenvironment, based on their physical characteristics, such as activation status, maturity, and polarization, illustrating a key role for DCs in the induction of anti-tumor immunity.

DOI10.12688/f1000research.14793.1
Alternate JournalF1000Res
PubMed ID30345015
PubMed Central IDPMC6173131

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