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2015
Bockman MR
,
Kalinda AS
,
Petrelli R
,
De la Mora-Rey T
,
Tiwari D
,
Liu F
,
Dawadi S
,
Nandakumar M
,
Rhee KY
,
Schnappinger D
et al.
. 2015.
Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
.
J Med Chem. 58(18):7349-7369.
Bockman MR
,
Kalinda AS
,
Petrelli R
,
De la Mora-Rey T
,
Tiwari D
,
Liu F
,
Dawadi S
,
Nandakumar M
,
Rhee KY
,
Schnappinger D
et al.
. 2015.
Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
.
J Med Chem. 58(18):7349-7369.
Garg A
,
Wesolowski D
,
Alonso D
,
Deitsch KW
,
Ben Mamoun C
,
Altman S
. 2015.
Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum.
.
Proc Natl Acad Sci U S A. 112(38):11935-40.
Ganapathy U
,
Marrero J
,
Calhoun S
,
Eoh H
,
de Carvalho LPedro Sori
,
Rhee K
,
Ehrt S
. 2015.
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.
.
Nat Commun. 6:7912.
Ukaegbu UE
,
Zhang X
,
Heinberg AR
,
Wele M
,
Chen Q
,
Deitsch KW
. 2015.
A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum.
.
PLoS Genet. 11(5):e1005234.
2016
Mesnard L
,
Muthukumar T
,
Burbach M
,
Li C
,
Shang H
,
Dadhania D
,
Lee JR
,
Sharma VK
,
Xiang J
,
Suberbielle C
et al.
. 2016.
Exome Sequencing and Prediction of Long-Term Kidney Allograft Function.
.
PLoS Comput Biol. 12(9):e1005088.
Zeng H
,
Guo M
,
Zhou T
,
Tan L
,
Chong CNok
,
Zhang T
,
Dong X
,
Xiang JZhaoying
,
Yu AS
,
Yue L
et al.
. 2016.
An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery.
.
Cell Stem Cell. 19(3):326-40.
Ramos-Espiritu L
,
Diaz A
,
Nardin C
,
Saviola AJ
,
Shaw F
,
Plitt T
,
Yang X
,
Wolchok J
,
Pirog EC
,
Desman G
et al.
. 2016.
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.
.
Oncotarget. 7(29):45597-45607.
Ramos-Espiritu L
,
Diaz A
,
Nardin C
,
Saviola AJ
,
Shaw F
,
Plitt T
,
Yang X
,
Wolchok J
,
Pirog EC
,
Desman G
et al.
. 2016.
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.
.
Oncotarget. 7(29):45597-45607.
Warrier T
,
Kapilashrami K
,
Argyrou A
,
Ioerger TR
,
Little D
,
Murphy KC
,
Nandakumar M
,
Park S
,
Gold B
,
Mi J
et al.
. 2016.
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
.
Proc Natl Acad Sci U S A. 113(31):E4523-30.
Gold B
,
Smith R
,
Nguyen Q
,
Roberts J
,
Ling Y
,
Quezada LLopez
,
Somersan S
,
Warrier T
,
Little D
,
Pingle M
et al.
. 2016.
Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis.
.
J Med Chem. 59(13):6027-44.
Van Voorhis WC
,
Adams JH
,
Adelfio R
,
Ahyong V
,
Akabas MH
,
Alano P
,
Alday A
,
Resto YAlemán
,
Alsibaee A
,
Alzualde A
et al.
. 2016.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
.
PLoS Pathog. 12(7):e1005763.
Van Voorhis WC
,
Adams JH
,
Adelfio R
,
Ahyong V
,
Akabas MH
,
Alano P
,
Alday A
,
Resto YAlemán
,
Alsibaee A
,
Alzualde A
et al.
. 2016.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
.
PLoS Pathog. 12(7):e1005763.
Van Voorhis WC
,
Adams JH
,
Adelfio R
,
Ahyong V
,
Akabas MH
,
Alano P
,
Alday A
,
Resto YAlemán
,
Alsibaee A
,
Alzualde A
et al.
. 2016.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
.
PLoS Pathog. 12(7):e1005763.
Van Voorhis WC
,
Adams JH
,
Adelfio R
,
Ahyong V
,
Akabas MH
,
Alano P
,
Alday A
,
Resto YAlemán
,
Alsibaee A
,
Alzualde A
et al.
. 2016.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
.
PLoS Pathog. 12(7):e1005763.
Van Voorhis WC
,
Adams JH
,
Adelfio R
,
Ahyong V
,
Akabas MH
,
Alano P
,
Alday A
,
Resto YAlemán
,
Alsibaee A
,
Alzualde A
et al.
. 2016.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
.
PLoS Pathog. 12(7):e1005763.
Van Voorhis WC
,
Adams JH
,
Adelfio R
,
Ahyong V
,
Akabas MH
,
Alano P
,
Alday A
,
Resto YAlemán
,
Alsibaee A
,
Alzualde A
et al.
. 2016.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
.
PLoS Pathog. 12(7):e1005763.
Yan W
,
Ding A
,
Kim H-J
,
Zheng H
,
Wei F
,
Ma X
. 2016.
Progranulin Controls Sepsis via C/EBPα-Regulated Il10 Transcription and Ubiquitin Ligase/Proteasome-Mediated Protein Degradation.
.
J Immunol. 197(8):3393-3405.
Chauhan R
,
Ravi J
,
Datta P
,
Chen T
,
Schnappinger D
,
Bassler KE
,
Balázsi G
,
Gennaro MLaura
. 2016.
Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis.
.
Nat Commun. 7:11062.
Korte J
,
Alber M
,
Trujillo CM
,
Syson K
,
Koliwer-Brandl H
,
Deenen R
,
Köhrer K
,
DeJesus MA
,
Hartman T
,
Jacobs WR
et al.
. 2016.
Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.
.
PLoS Pathog. 12(12):e1006043.
Korte J
,
Alber M
,
Trujillo CM
,
Syson K
,
Koliwer-Brandl H
,
Deenen R
,
Köhrer K
,
DeJesus MA
,
Hartman T
,
Jacobs WR
et al.
. 2016.
Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.
.
PLoS Pathog. 12(12):e1006043.
2017
Huffman JB
,
Daniel GR
,
Falck-Pedersen E
,
Huet A
,
Smith GA
,
Conway JF
,
Homa FL
. 2017.
The C Terminus of the Herpes Simplex Virus UL25 Protein Is Required for Release of Viral Genomes from Capsids Bound to Nuclear Pores.
.
J Virol. 91(15)
Xu W
,
DeJesus MA
,
Rücker N
,
Engelhart CA
,
Wright MG
,
Healy C
,
Lin K
,
Wang R
,
Park SWoong
,
Ioerger TR
et al.
. 2017.
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
.
Antimicrob Agents Chemother. 61(12)
Calhoun SF
,
Reed J
,
Alexander N
,
Mason CE
,
Deitsch KW
,
Kirkman LA
. 2017.
Chromosome End Repair and Genome Stability in .
.
mBio. 8(4)
Zhao Q
,
Du Q
,
Wei F
,
Xie J
,
Ma X
. 2017.
An Infectious Disease-Associated Il12b Polymorphism Regulates IL-12/23 p40 Transcription Involving Poly(ADP-Ribose) Polymerase 1.
.
J Immunol. 198(7):2935-2942.
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