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Publications

Found 63 results
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2021
Zhang L, Jiang X, Pfau D, Ling Y, Nathan CF.  2021.  Type I interferon signaling mediates Mycobacterium tuberculosis-induced macrophage death.. J Exp Med. 218(2)
2020
Song M, Wang C, Wang H, Zhang T, Li J, Benezra R, Chouchane L, Sun Y-H, Cui X-G, Ma X.  2020.  Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response.. Oncoimmunology. 9(1):1746148.
Gengenbacher M, Zimmerman MD, Sarathy JP, Kaya F, Wang H, Mina M, Carter C, Hossen MAmir, Su H, Trujillo C et al..  2020.  Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.. Antimicrob Agents Chemother. 64(5)
2019
Wang K-J, Wang C, Dai L-H, Yang J, Huang H, Ma X-J, Zhou Z, Yang Z-Y, Xu W-D, Hua M-M et al..  2019.  Targeting an Autocrine Regulatory Loop in Cancer Stem-like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer.. Clin Cancer Res. 25(3):1070-1086.
Yu EYoung, Cheung IY, Feng Y, Rabie MO, Roboz GJ, Guzman ML, Cheung N-KV, Lue NF.  2019.  Telomere Trimming and DNA Damage as Signatures of High Risk Neuroblastoma.. Neoplasia. 21(7):689-701.
Lee JJin, Lee S-K, Song N, Nathan TO, Swarts BM, Eum S-Y, Ehrt S, Cho S-N, Eoh H.  2019.  Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis.. Nat Commun. 10(1):2928.
2018
Rafiq S, Yeku OO, Jackson HJ, Purdon TJ, van Leeuwen DG, Drakes DJ, Song M, Miele MM, Li Z, Wang P et al..  2018.  Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo.. Nat Biotechnol. 36(9):847-856.
Tiwari D, Park SWoong, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HPin, Engelhart CA et al..  2018.  Targeting protein biotinylation enhances tuberculosis chemotherapy.. Sci Transl Med. 10(438)
2017
Ban Y, Mai J, Li X, Mitchell-Flack M, Zhang T, Zhang L, Chouchane L, Ferrari M, Shen H, Ma X.  2017.  Targeting Autocrine CCL5-CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity.. Cancer Res. 77(11):2857-2868.
Gold B, Nathan C.  2017.  Targeting Phenotypically Tolerant Mycobacterium tuberculosis.. Microbiol Spectr. 5(1)
Lue NF, Yu EYoung.  2017.  Telomere recombination pathways: tales of several unhappy marriages.. Curr Genet. 63(3):401-409.
2016
Li W, Obregón-Henao A, Wallach JB, E North J, Lee RE, Gonzalez-Juarrero M, Schnappinger D, Jackson M.  2016.  Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3.. Antimicrob Agents Chemother. 60(9):5198-207.
Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR et al..  2016.  Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.. PLoS Pathog. 12(12):e1006043.
2015
Park SWoong, Casalena DE, Wilson DJ, Dai R, Nag PP, Liu F, Boyce JP, Bittker JA, Schreiber SL, Finzel BC et al..  2015.  Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.. Chem Biol. 22(1):76-86.
Zhao N, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED et al..  2015.  Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.. ACS Chem Biol. 10(2):364-71.
Bockman MR, Kalinda AS, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, Dawadi S, Nandakumar M, Rhee KY, Schnappinger D et al..  2015.  Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.. J Med Chem. 58(18):7349-7369.
Garg A, Wesolowski D, Alonso D, Deitsch KW, Ben Mamoun C, Altman S.  2015.  Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum.. Proc Natl Acad Sci U S A. 112(38):11935-40.
Nathan C, Barry CE.  2015.  TB drug development: immunology at the table.. Immunol Rev. 264(1):308-18.
Steinberg-Neifach O, Lue NF.  2015.  Telomere DNA recognition in Saccharomycotina yeast: potential lessons for the co-evolution of ssDNA and dsDNA-binding proteins and their target sites.. Front Genet. 6:162.
Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LPedro Sori, Rhee K, Ehrt S.  2015.  Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.. Nat Commun. 6:7912.
2014
Kafsack BFC, Rovira-Graells N, Clark TG, Bancells C, Crowley VM, Campino SG, Williams AE, Drought LG, Kwiatkowski DP, Baker DA et al..  2014.  A transcriptional switch underlies commitment to sexual development in malaria parasites.. Nature. 507(7491):248-52.
Trujillo C, Blumenthal A, Marrero J, Rhee KY, Schnappinger D, Ehrt S.  2014.  Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection.. mBio. 5(2):e00085.
2013
Lue NF, Zhou R, Chico L, Mao N, Steinberg-Neifach O, Ha T.  2013.  The telomere capping complex CST has an unusual stoichiometry, makes multipartite interaction with G-Tails, and unfolds higher-order G-tail structures.. PLoS Genet. 9(1):e1003145.
Noti M, Wojno EDTait, Kim BS, Siracusa MC, Giacomin PR, Nair MG, Benitez AJ, Ruymann KR, Muir AB, Hill DA et al..  2013.  Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.. Nat Med. 19(8):1005-13.
Siracusa MC, Saenz SA, Wojno EDTait, Kim BS, Osborne LC, Ziegler CG, Benitez AJ, Ruymann KR, Farber DL, Sleiman PM et al..  2013.  Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation.. Immunity. 39(6):1158-70.