Microbiology and Immunology

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Found 259 results

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2026

Hunt DM, Pisco JPedro, Rodgers A, de Chiara C, Zaveri A, Pacholarz KL, Evangelopoulos D, Garza-Garcia A, Ehrt S, Schnappinger D et al.. 2026. Activation of L-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis.. Nat Commun. 17(1)

Liu Q, Engelhart CA, Wallach JB, Ge P, Wong T-Y, Orimoloye MO, Rodriguez S, Jayasinghe YP, Ronning DR, Dartois V et al.. 2026. Design, Synthesis and Biological Evaluation of Potent Piperazine-Based BioA Inhibitors Targeting Biotin Biosynthesis in Mycobacterium tuberculosis.. J Med Chem.

Khonde LPeguy, Peton N, Masike K, Valentine T, Zindo F, Fienberg S, Omollo C, Njoroge M, Vallini F, Tammaro C et al.. 2026. Structure-Activity relationship and optimization of drug-like properties of antituberculosis 3-(4,4-dimethyl-1,4-azasilinane)methylpyrazole MmpL3 inhibitors.. Eur J Med Chem. 312:118841.

2025

Yang Z, Zhang L, Ottavi S, Geri JB, Perkowski A, Jiang X, Pfau D, Bryk R, Aubé J, Zimmerman M et al.. 2025. ACOD1-mediated lysosomal membrane permeabilization contributes to Mycobacterium tuberculosis-induced macrophage death.. Proc Natl Acad Sci U S A. 122(12):e2425309122.

Yang Z, Zhang L, Ottavi S, Geri JB, Perkowski A, Jiang X, Pfau D, Bryk R, Aubé J, Zimmerman M et al.. 2025. ACOD1-mediated lysosomal membrane permeabilization contributes to Mycobacterium tuberculosis-induced macrophage death.. Proc Natl Acad Sci U S A. 122(12):e2425309122.

Wu X, Huang S, Gao J, Huang S, Chen L, Zhao Z, Pu R, Ma X, Liu X, He W et al.. 2025. AKR1B10 dictates c-Myc stability to suppress colorectal cancer metastasis via PP2A nitration.. Sci Adv. 11(34):eadv6937.

Mishra S, Singh PRanjan, Hu X, Lopez-Quezada L, Jinich A, Jahn R, Geurts L, Shen N, DeJesus MA, Hartman T et al.. 2025. Candidate transmission survival genome of Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 122(10):e2425981122.

J Vandana J, Zhu J, Giani AMaria, Zhang T, Lacko LA, Leng D, D Taylor L, Lee BN, Han Z, Jiao T et al.. 2025. ChemPerturb-seq screen identifies a small molecule cocktail enhancing human beta cell survival after subcutaneous transplantation.. Cell Stem Cell. 32(8):1299-1307.e8.

J Vandana J, Zhu J, Giani AMaria, Zhang T, Lacko LA, Leng D, D Taylor L, Lee BN, Han Z, Jiao T et al.. 2025. ChemPerturb-seq screen identifies a small molecule cocktail enhancing human beta cell survival after subcutaneous transplantation.. Cell Stem Cell. 32(8):1299-1307.e8.

J Vandana J, Zhu J, Giani AMaria, Zhang T, Lacko LA, Leng D, D Taylor L, Lee BN, Han Z, Jiao T et al.. 2025. ChemPerturb-seq screen identifies a small molecule cocktail enhancing human beta cell survival after subcutaneous transplantation.. Cell Stem Cell. 32(8):1299-1307.e8.

Davis SH, Mathieson M, Buchanan KI, Dawson A, Smith A, Cocco M, Tamaki FK, Post JM, Baragaña B, Jansen C et al.. 2025. Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis.. J Med Chem. 68(15):16459-16482.

Wang X, Su H, Wallach JB, Wagner JC, Braunecker BJ, Gardner M, Guinn KM, Howard NC, Klevorn T, Lin K et al.. 2025. Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models.. Nat Microbiol. 10(2):482-494.

Wang X, Su H, Wallach JB, Wagner JC, Braunecker BJ, Gardner M, Guinn KM, Howard NC, Klevorn T, Lin K et al.. 2025. Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models.. Nat Microbiol. 10(2):482-494.

Han Y, Leng D, Zhang T, Ge J, Fang Y, Lu T, Dong X, Nair MS, de Silva N, Han Z et al.. 2025. A Human Immuno-Lung Organoid Model to Study Macrophage-Mediated Lung Cell Senescence Upon SARS-CoV-2 Infection.. Adv Sci (Weinh). 12(36):e03932.

Han Y, Leng D, Zhang T, Ge J, Fang Y, Lu T, Dong X, Nair MS, de Silva N, Han Z et al.. 2025. A Human Immuno-Lung Organoid Model to Study Macrophage-Mediated Lung Cell Senescence Upon SARS-CoV-2 Infection.. Adv Sci (Weinh). 12(36):e03932.

Zhou W, Zhou JZ, Ahmed A, Kim MJoon, Guo C-J, Sonnenberg GF. 2025. ILC3s sense gut microbiota through STING to initiate immune tolerance.. Immunity. 58(7):1762-1777.e7.

Zhou W, Zhou JZ, Ahmed A, Kim MJoon, Guo C-J, Sonnenberg GF. 2025. ILC3s sense gut microbiota through STING to initiate immune tolerance.. Immunity. 58(7):1762-1777.e7.

Laurent P, Chaudhary V, Li D, Kioon MDominique, Zhang C, Miller WH, Liao H, Lin G, Nathan CF, Barrat FJ. 2025. The immunoproteasome regulates ILC2 responses by modulating mitochondrial capacity.. Proc Natl Acad Sci U S A. 122(47):e2518190122.

Liu Q, Engelhart CA, Wallach JB, Tiwari D, Ge P, Manna A, Panda S, McCue WM, Wong T-Y, Sharma S et al.. 2025. Metabolically Stable Adenylation Inhibitors of Biotin Protein Ligase as Antibacterial Agents.. J Med Chem. 68(3):3065-3087.

Zhang M, Allen R, Ames L, Engelhart CA, Quach D, Lv X, Xiao G, Wang H, Wang J, Zhou L et al.. 2025. Microbiological evidence for the trisubstituted benzimidazoles targeting MmpL3 in Mycobacterium tuberculosis.. Antimicrob Agents Chemother. :e0036825.

Zhang M, Allen R, Ames L, Engelhart CA, Quach D, Lv X, Xiao G, Wang H, Wang J, Zhou L et al.. 2025. Microbiological evidence for the trisubstituted benzimidazoles targeting MmpL3 in Mycobacterium tuberculosis.. Antimicrob Agents Chemother. :e0036825.

Iliev ID, J Blander M, Collins N, Guo C-J, Longman RS, Sonnenberg GF, Zeng MY, Artis D. 2025. Microbiota-mediated mechanisms of mucosal immunity across the lifespan.. Nat Immunol.

Jinich A, Zaveri A, DeJesus MA, Spencer A, Almada-Monter R, Flores-Bautista E, Smith CM, Sassetti CM, Rock JM, Ehrt S et al.. 2025. The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB): A Large-Scale Guide to Genetic Conditional Essentiality.. Mol Microbiol. 124(1):91-101.

Vishwanatha A, Zhang X, Liu YJing, Leung A, Herring M, Visone J, Chan A, Calhoun S, Deitsch K, Kirkman L. 2025. Plasmodium falciparum DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification.. Nucleic Acids Res. 53(21)

Vishwanatha A, Zhang X, Liu YJing, Leung A, Herring M, Chan A, Calhoun S, Deitsch K, Kirkman L. 2025. Plasmodium falciparum DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification.. bioRxiv.