Microbiology and Immunology

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2023

Green SR, Wilson C, Eadsforth TC, Punekar AS, Tamaki FK, Wood G, Caldwell N, Forte B, Norcross NR, Kiczun M et al.. 2023. Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.. J Med Chem. 66(22):15380-15408.

Green SR, Wilson C, Eadsforth TC, Punekar AS, Tamaki FK, Wood G, Caldwell N, Forte B, Norcross NR, Kiczun M et al.. 2023. Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.. J Med Chem. 66(22):15380-15408.

Green SR, Wilson C, Eadsforth TC, Punekar AS, Tamaki FK, Wood G, Caldwell N, Forte B, Norcross NR, Kiczun M et al.. 2023. Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.. J Med Chem. 66(22):15380-15408.

Green SR, Wilson C, Eadsforth TC, Punekar AS, Tamaki FK, Wood G, Caldwell N, Forte B, Norcross NR, Kiczun M et al.. 2023. Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.. J Med Chem. 66(22):15380-15408.

Sharma R, Hartman TE, Beites T, Kim J-H, Eoh H, Engelhart CA, Zhu L, Wilson DJ, Aldrich CC, Ehrt S et al.. 2023. Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis.. mBio. 14(4):e0034023.

Wang F, He Q, Zhan W, Yu Z, Finkin-Groner E, Ma X, Lin G, Li H. 2023. Structure of the human UBR5 E3 ubiquitin ligase.. Structure. 31(5):541-552.e4.

Zhang H, Ginn J, Zhan W, Leung A, Liu YJ, Toita A, Okamoto R, Wong T-T, Imaeda T, Hara R et al.. 2023. Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II.. J Med Chem. 66(2):1484-1508.

2022

Gourari I, Gomi R, Young M, Jordan G, Liongson M, Heras A, Gerber LM, Thomas C, Tsirilakis K, Ono J et al.. 2022. Asthma 17q21 polymorphism associates with decreased risk of COVID-19 in children.. Pediatr Pulmonol. 57(11):2855-2860.

Heydarchi B, Fong DS, Gao H, Salazar-Quiroz NA, Edwards JM, Gonelli CA, Grimley S, Aktepe TE, Mackenzie C, Wales WJ et al.. 2022. Broad and ultra-potent cross-clade neutralization of HIV-1 by a vaccine-induced CD4 binding site bovine antibody.. Cell Rep Med. 3(5):100635.

Moretti J, Jia B, Hutchins Z, Roy S, Yip H, Wu J, Shan M, Jaffrey SR, Coers J, J Blander M. 2022. Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome.. Nat Immunol. 23(5):705-717.

Chaudhary V, Kioon MDominique, Hwang S-M, Mishra B, Lakin K, Kirou KA, Zhang-Sun J, R Wiseman L, Spiera RF, Crow MK et al.. 2022. Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses.. J Exp Med. 219(11)

Kreutzfeldt KM, Jansen RS, Hartman TE, Gouzy A, Wang R, Krieger IV, Zimmerman MD, Gengenbacher M, Sarathy JP, Xie M et al.. 2022. CinA mediates multidrug tolerance in Mycobacterium tuberculosis.. Nat Commun. 13(1):2203.

Zhang H, Ginn J, Zhan W, Liu YJ, Leung A, Toita A, Okamoto R, Wong T-T, Imaeda T, Hara R et al.. 2022. Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors.. J Med Chem. 65(13):9350-9375.

Schorcht A, Cottrell CA, Pugach P, Ringe RP, Han AX, Allen JD, van den Kerkhof TLGM, Seabright GE, Schermer EE, Ketas TJ et al.. 2022. The Glycan Hole Area of HIV-1 Envelope Trimers Contributes Prominently to the Induction of Autologous Neutralization.. J Virol. 96(1):e0155221.

Gold B, Zhang J, Quezada LLopez, Roberts J, Ling Y, Wood M, Shinwari W, Goullieux L, Roubert C, Fraisse L et al.. 2022. Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions.. ACS Infect Dis. 8(3):557-573.

Lyu M, Suzuki H, Kang L, Gaspal F, Zhou W, Goc J, Zhou L, Zhou J, Zhang W, Shen Z et al.. 2022. ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut.. Nature. 610(7933):744-751.

Green SR, Davis SH, Damerow S, Engelhart CA, Mathieson M, Baragaña B, Robinson DA, Tamjar J, Dawson A, Tamaki FK et al.. 2022. Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.. Nat Commun. 13(1):5992.

Green SR, Davis SH, Damerow S, Engelhart CA, Mathieson M, Baragaña B, Robinson DA, Tamjar J, Dawson A, Tamaki FK et al.. 2022. Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.. Nat Commun. 13(1):5992.

Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M et al.. 2022. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.. J Med Chem. 65(1):409-423.

Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M et al.. 2022. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.. J Med Chem. 65(1):409-423.

Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M et al.. 2022. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.. J Med Chem. 65(1):409-423.

Zhang L, Kent JE, Whitaker M, Young DC, Herrmann D, Aleshin AE, Ko Y-H, Cingolani G, Saad JS, D Moody B et al.. 2022. A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis.. Nat Commun. 13(1):2255.

Walsh KF, Lee MHee, Brejt JA, Reust MJ, Juste MJean, Hilaire G, Pape JWilliam, Koenig S, Dupnik K. 2022. Prevalence of HTLV-I Infection and Its Association with Tuberculosis among Patients at an Urban Clinic in Haiti.. Am J Trop Med Hyg. 106(5):1333-5.

Zainabadi K, Saito K, Mishra S, Walsh KFrances, Mathurin LDaniel, Vilbrun SCharles, Ocheretina O, Pape JWilliam, Fitzgerald DW, Nathan CF et al.. 2022. Transcriptional Biomarkers of Differentially Detectable Mycobacterium tuberculosis in Patient Sputum.. mBio. 13(6):e0270122.

Wu B, Song M, Dong Q, Xiang G, Li J, Ma X, Wei F. 2022. UBR5 promotes tumor immune evasion through enhancing IFN-γ-induced PDL1 transcription in triple negative breast cancer.. Theranostics. 12(11):5086-5102.