Microbiology and Immunology

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2024

Qu D, Ge P, Botella L, Park SWoong, Lee H-N, Thornton N, Bean JM, Krieger IV, Sacchettini JC, Ehrt S et al.. 2024. Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin.. Nat Commun. 15(1):4161.

Singh A, Ottavi S, Krieger I, Planck K, Perkowski A, Kaneko T, Davis AM, Suh C, Zhang D, Goullieux L et al.. 2024. Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.. Sci Adv. 10(11):eadj6406.

Arias AA, Neehus A-L, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J et al.. 2024. Tuberculosis in otherwise healthy adults with inherited TNF deficiency.. Nature. 633(8029):417-425.

Arias AA, Neehus A-L, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J et al.. 2024. Tuberculosis in otherwise healthy adults with inherited TNF deficiency.. Nature. 633(8029):417-425.

Hahn WO, K Parks R, Shen M, Ozorowski G, Janes H, Ballweber-Fleming L, Davis ASWoodward, Duplessis C, Tomai M, Dey AK et al.. 2024. Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies.. J Exp Med. 221(10)

Hahn WO, K Parks R, Shen M, Ozorowski G, Janes H, Ballweber-Fleming L, Davis ASWoodward, Duplessis C, Tomai M, Dey AK et al.. 2024. Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies.. J Exp Med. 221(10)

Hahn WO, K Parks R, Shen M, Ozorowski G, Janes H, Ballweber-Fleming L, Davis ASWoodward, Duplessis C, Tomai M, Dey AK et al.. 2024. Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies.. J Exp Med. 221(10)

2023

Zi Z, Du S, Zhang L, Wang Y, Ding L, Zhang C, Wang H, Pawlicki J, Cai Y, Yao Y et al.. 2023. Aberrant expression of GOLM1 protects ALK+ anaplastic large cell lymphoma from apoptosis by enhancing BCL-XL stability.. Blood Adv. 7(15):4049-4063.

Green SR, Wilson C, Eadsforth TC, Punekar AS, Tamaki FK, Wood G, Caldwell N, Forte B, Norcross NR, Kiczun M et al.. 2023. Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.. J Med Chem. 66(22):15380-15408.

Harris CT, Tong X, Campelo R, Marreiros IM, Vanheer LN, Nahiyaan N, Zuzarte-Luís VA, Deitsch KW, Mota MM, Rhee KY et al.. 2023. Sexual differentiation in human malaria parasites is regulated by competition between phospholipid metabolism and histone methylation.. Nat Microbiol. 8(7):1280-1292.

Zhang H, Ginn J, Zhan W, Leung A, Liu YJ, Toita A, Okamoto R, Wong T-T, Imaeda T, Hara R et al.. 2023. Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II.. J Med Chem. 66(2):1484-1508.

Zhang H, Ginn J, Zhan W, Leung A, Liu YJ, Toita A, Okamoto R, Wong T-T, Imaeda T, Hara R et al.. 2023. Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II.. J Med Chem. 66(2):1484-1508.

2022

Gourari I, Gomi R, Young M, Jordan G, Liongson M, Heras A, Gerber LM, Thomas C, Tsirilakis K, Ono J et al.. 2022. Asthma 17q21 polymorphism associates with decreased risk of COVID-19 in children.. Pediatr Pulmonol. 57(11):2855-2860.

Gourari I, Gomi R, Young M, Jordan G, Liongson M, Heras A, Gerber LM, Thomas C, Tsirilakis K, Ono J et al.. 2022. Asthma 17q21 polymorphism associates with decreased risk of COVID-19 in children.. Pediatr Pulmonol. 57(11):2855-2860.

Koh E-I, Oluoch PO, Ruecker N, Proulx MK, Soni V, Murphy KC, Papavinasasundaram K, Reames CJ, Trujillo C, Zaveri A et al.. 2022. Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.. Proc Natl Acad Sci U S A. 119(15):e2201632119.

Zhang H, Ginn J, Zhan W, Liu YJ, Leung A, Toita A, Okamoto R, Wong T-T, Imaeda T, Hara R et al.. 2022. Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors.. J Med Chem. 65(13):9350-9375.

Ottavi S, Scarry SM, Mosior J, Ling Y, Roberts J, Singh A, Zhang D, Goullieux L, Roubert C, Bacqué E et al.. 2022. In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.. J Med Chem. 65(3):1996-2022.

Green SR, Davis SH, Damerow S, Engelhart CA, Mathieson M, Baragaña B, Robinson DA, Tamjar J, Dawson A, Tamaki FK et al.. 2022. Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.. Nat Commun. 13(1):5992.

Green SR, Davis SH, Damerow S, Engelhart CA, Mathieson M, Baragaña B, Robinson DA, Tamjar J, Dawson A, Tamaki FK et al.. 2022. Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.. Nat Commun. 13(1):5992.

Green SR, Davis SH, Damerow S, Engelhart CA, Mathieson M, Baragaña B, Robinson DA, Tamjar J, Dawson A, Tamaki FK et al.. 2022. Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.. Nat Commun. 13(1):5992.

Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M et al.. 2022. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.. J Med Chem. 65(1):409-423.

Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M et al.. 2022. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.. J Med Chem. 65(1):409-423.

Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M et al.. 2022. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.. J Med Chem. 65(1):409-423.

Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M et al.. 2022. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.. J Med Chem. 65(1):409-423.

Laurent P, Yang C, Rendeiro AF, Nilsson-Payant BE, Carrau L, Chandar V, Bram Y, tenOever BR, Elemento O, Ivashkiv LB et al.. 2022. Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19.. Sci Immunol. 7(75):eadd4906.