Microbiology and Immunology

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2025
Mostert D, Braun J, Zimmerman MD, Engelhart CA, Berndl S, Quoika PK, Kany AM, Proietto J, Penalva-Lopez S, Wallach JB et al..  2025.  Tailored phenyl ureas eradicate drug-resistant Mycobacterium tuberculosis by targeting mycolic acid cell wall assembly.. Chem Sci. 16(21):9472-9483.
Schwer B, Prucker I, Sanchez AM, Babor J, Jessen HJ, Shuman S.  2025.  Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast.. mBio. 16(5):e0038925.
Singh A, Zwerneman LT, Planck K, Kaneko T, Perkowski AJ, Suh CM, Alex A, Bean J, Burns-Huang K, Zhang D et al..  2025.  Thioquinazolinones as Antituberculosis Agents Targeting Phosphopantetheinyl Transferase.. J Med Chem. 68(14):14645-14698.
Singh A, Zwerneman LT, Planck K, Kaneko T, Perkowski AJ, Suh CM, Alex A, Bean J, Burns-Huang K, Zhang D et al..  2025.  Thioquinazolinones as Antituberculosis Agents Targeting Phosphopantetheinyl Transferase.. J Med Chem. 68(14):14645-14698.
Itkin T, Houghton S, Schreiner R, Lin Y, Badwe CR, Voisin V, Murison A, Seyedhassantehrani N, Kaufmann KB, Garcia-Prat L et al..  2025.  Transcriptional activation of regenerative hematopoiesis via microenvironmental sensing.. Nat Immunol. 26(3):378-390.
2024
Ghosh S, Sanchez AM, Schwer B, Prucker I, Jork N, Jessen HJ, Shuman S.  2024.  Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase.. mBio. 15(8):e0108424.
Giardina SF, Valdambrini E, Singh PK, Bacolod MD, Babu-Karunakaran G, Peel M, J Warren D, Barany F.  2024.  Combinatorial Ubiquitination REal-time PROteolysis (CURE-PROs): A Modular Platform for Generating Reversible, Self-Assembling Bifunctional Targeted Degraders.. J Med Chem. 67(7):5473-5501.
Grigsby SJ, Prasad GVRKrishn, Wallach JB, Mittal E, Hsu F-F, Schnappinger D, Philips JA.  2024.  CpsA mediates infection of recruited lung myeloid cells by Mycobacterium tuberculosis.. Cell Rep. 43(1):113607.
Grigsby SJ, Prasad GVRKrishn, Wallach JB, Mittal E, Hsu F-F, Schnappinger D, Philips JA.  2024.  CpsA mediates infection of recruited lung myeloid cells by Mycobacterium tuberculosis.. Cell Rep. 43(1):113607.
Caniels TG, Medina-Ramírez M, Zhang S, Kratochvil S, Xian Y, Koo J-H, Derking R, Samsel J, van Schooten J, Pecetta S et al..  2024.  Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site.. Sci Immunol. 9(98):eadk9550.
Caniels TG, Medina-Ramírez M, Zhang S, Kratochvil S, Xian Y, Koo J-H, Derking R, Samsel J, van Schooten J, Pecetta S et al..  2024.  Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site.. Sci Immunol. 9(98):eadk9550.
Alwine J, Goodrum F, Banfield B, Bloom D, Britt WJ, Broadbent AJ, Campos SK, Casadevall A, Chan GC, Cliffe AR et al..  2024.  The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence.. J Virol. 98(9):e0124024.
Alwine J, Goodrum F, Banfield B, Bloom D, Britt WJ, Broadbent AJ, Campos SK, Casadevall A, Chan GC, Cliffe AR et al..  2024.  The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence.. J Virol. 98(9):e0124024.
Alwine J, Goodrum F, Banfield B, Bloom D, Britt WJ, Broadbent AJ, Campos SK, Casadevall A, Chan GC, Cliffe AR et al..  2024.  The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence.. J Virol. 98(9):e0124024.
Alwine J, Goodrum F, Banfield B, Bloom D, Britt WJ, Broadbent AJ, Campos SK, Casadevall A, Chan GC, Cliffe AR et al..  2024.  The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence.. J Virol. 98(9):e0124024.
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA et al..  2024.  Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques.. Sci Immunol. 9(98):eadm7097.
Qu D, Ge P, Botella L, Park SWoong, Lee H-N, Thornton N, Bean JM, Krieger IV, Sacchettini JC, Ehrt S et al..  2024.  Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin.. Nat Commun. 15(1):4161.
Juste MAntoine Je, Joseph Y, Lespinasse D, Apollon A, Jamshidi P, Lee MHee, Ward M, Brill E, Duffus Y, Chukwukere U et al..  2024.  People Living With HIV Have More Intact HIV DNA in Circulating CD4+ T Cells if They Have History of Pulmonary Tuberculosis.. Pathog Immun. 9(2):172-193.
Dupnik K, Rivera VR, Dorvil N, Duffus Y, Akbarnejad H, Gao Y, Liu J, Apollon A, Dumont E, Riviere C et al..  2024.  Potential Utility of C-reactive Protein for Tuberculosis Risk Stratification Among Patients With Non-Meningitic Symptoms at HIV Diagnosis in Low- and Middle-income Countries.. Open Forum Infect Dis. 11(7):ofae356.
Dupnik K, Rivera VR, Dorvil N, Duffus Y, Akbarnejad H, Gao Y, Liu J, Apollon A, Dumont E, Riviere C et al..  2024.  Potential Utility of C-reactive Protein for Tuberculosis Risk Stratification Among Patients With Non-Meningitic Symptoms at HIV Diagnosis in Low- and Middle-income Countries.. Open Forum Infect Dis. 11(7):ofae356.
Singh A, Ottavi S, Krieger I, Planck K, Perkowski A, Kaneko T, Davis AM, Suh C, Zhang D, Goullieux L et al..  2024.  Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.. Sci Adv. 10(11):eadj6406.
Singh A, Ottavi S, Krieger I, Planck K, Perkowski A, Kaneko T, Davis AM, Suh C, Zhang D, Goullieux L et al..  2024.  Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.. Sci Adv. 10(11):eadj6406.
Singh A, Ottavi S, Krieger I, Planck K, Perkowski A, Kaneko T, Davis AM, Suh C, Zhang D, Goullieux L et al..  2024.  Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.. Sci Adv. 10(11):eadj6406.
Arias AA, Neehus A-L, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J et al..  2024.  Tuberculosis in otherwise healthy adults with inherited TNF deficiency.. Nature. 633(8029):417-425.
Arias AA, Neehus A-L, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J et al..  2024.  Tuberculosis in otherwise healthy adults with inherited TNF deficiency.. Nature. 633(8029):417-425.