Microbiology and Immunology

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Found 86 results

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2017

Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt S. 2017. Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 114(11):E2225-E2232.

2018

Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M et al.. 2018. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.. Proc Natl Acad Sci U S A. 115(29):E6863-E6870.

Negri A, Javidnia P, Mu R, Zhang X, Vendome J, Gold B, Roberts J, Barman D, Ioerger T, Sacchettini JC et al.. 2018. Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.. ACS Infect Dis. 4(5):771-787.

Tiwari D, Park SWoong, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HPin, Engelhart CA et al.. 2018. Targeting protein biotinylation enhances tuberculosis chemotherapy.. Sci Transl Med. 10(438)

2019

Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N et al.. 2019. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.. Nature. 571(7763):72-78.

Ballinger E, Mosior J, Hartman T, Burns-Huang K, Gold B, Morris R, Goullieux L, Blanc I, Vaubourgeix J, Lagrange S et al.. 2019. Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.. Science. 363(6426)

Zhan W, Hsu H-C, Morgan T, Ouellette T, Burns-Huang K, Hara R, Wright AG, Imaeda T, Okamoto R, Sato K et al.. 2019. Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome.. J Med Chem. 62(20):9246-9253.

Subramaniyam S, DeJesus MA, Zaveri A, Smith CM, Baker RE, Ehrt S, Schnappinger D, Sassetti CM, Ioerger TR. 2019. Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression.. BMC Bioinformatics. 20(1):603.

2021

Zhan W, Zhang H, Ginn J, Leung A, Liu YJ, Michino M, Toita A, Okamoto R, Wong T-T, Imaeda T et al.. 2021. Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.. Angew Chem Int Ed Engl. 60(17):9279-9283.

Su H, Lin K, Tiwari D, Healy C, Trujillo C, Liu Y, Ioerger TR, Schnappinger D, Ehrt S. 2021. Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity.. J Exp Med. 218(9)

Dutta E, DeJesus MA, Ruecker N, Zaveri A, Koh E-I, Sassetti CM, Schnappinger D, Ioerger TR. 2021. An improved statistical method to identify chemical-genetic interactions by exploiting concentration-dependence.. PLoS One. 16(10):e0257911.

Zhang H, Hsu H-C, Kahne SC, Hara R, Zhan W, Jiang X, Burns-Huang K, Ouellette T, Imaeda T, Okamoto R et al.. 2021. Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.. J Med Chem. 64(9):6262-6272.

Athapattu US, Amarasekara CA, Immel JR, Bloom S, Barany F, Nagel AC, Soper SA. 2021. Solid-phase XRN1 reactions for RNA cleavage: application in single-molecule sequencing.. Nucleic Acids Res. 49(7):e41.

2022

Koh E-I, Oluoch PO, Ruecker N, Proulx MK, Soni V, Murphy KC, Papavinasasundaram K, Reames CJ, Trujillo C, Zaveri A et al.. 2022. Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.. Proc Natl Acad Sci U S A. 119(15):e2201632119.

Du Y, Kioon MDominique, Laurent P, Chaudhary V, Pierides M, Yang C, Oliver D, Ivashkiv LB, Barrat FJ. 2022. Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation.. J Exp Med. 219(7)

Zhang H, Ginn J, Zhan W, Liu YJ, Leung A, Toita A, Okamoto R, Wong T-T, Imaeda T, Hara R et al.. 2022. Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors.. J Med Chem. 65(13):9350-9375.

Smith CM, Baker RE, Proulx MK, Mishra BB, Long JE, Park SWoong, Lee H-N, Kiritsy MC, Bellerose MM, Olive AJ et al.. 2022. Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice.. Elife. 11

Laurent P, Yang C, Rendeiro AF, Nilsson-Payant BE, Carrau L, Chandar V, Bram Y, tenOever BR, Elemento O, Ivashkiv LB et al.. 2022. Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19.. Sci Immunol. 7(75):eadd4906.

2023

Prabhu M, Yang YJ, Johnston CD, Murphy EA, Ketas TJ, Díaz-Tapia R, Jurkiewicz M, Racine-Brzostek S, Mohammed I, Sukhu AC et al.. 2023. Longitudinal antibody response kinetics following SARS-CoV-2 messenger RNA vaccination in pregnant and nonpregnant persons.. Am J Obstet Gynecol MFM. 5(2):100796.

Zhang H, Ginn J, Zhan W, Leung A, Liu YJ, Toita A, Okamoto R, Wong T-T, Imaeda T, Hara R et al.. 2023. Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II.. J Med Chem. 66(2):1484-1508.

2024

Choudhery S, DeJesus MA, Srinivasan A, Rock J, Schnappinger D, Ioerger TR. 2024. A dose-response model for statistical analysis of chemical genetic interactions in CRISPRi screens.. PLoS Comput Biol. 20(5):e1011408.

Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA et al.. 2024. Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques.. Sci Immunol. 9(98):eadm7097.

Sim JHyun, Bell R, Feng Z, Chyou S, Shipman WD, Kataru RP, Ivashkiv L, Mehrara B, Lu TT. 2024. Langerhans cells regulate immunity in adulthood by regulating postnatal dermal lymphatic development.. bioRxiv.

Schwer B, Innokentev A, Sanchez AM, Garg A, Shuman S. 2024. Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1.. mBio. 15(7):e0125224.

2025

Palme PR, Grover S, Abdelaziz R, Mann L, Kany AM, Ouologuem L, Bartel K, Sonnenkalb L, Reiling N, Hirsch AKH et al.. 2025. Design, Synthesis, and Biological Evaluation of Mono- and Diamino-Substituted Squaramide Derivatives as Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthase.. J Med Chem.