Microbiology and Immunology

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Found 162 results

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2015

Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LPedro Sori, Rhee K, Ehrt S. 2015. Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.. Nat Commun. 6:7912.

Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LPedro Sori, Rhee K, Ehrt S. 2015. Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.. Nat Commun. 6:7912.

2016

Schnappinger D, Ehrt S. 2016. A broader spectrum of tuberculosis.. Nat Med. 22(10):1076-1077.

Zeng H, Guo M, Zhou T, Tan L, Chong CNok, Zhang T, Dong X, Xiang JZhaoying, Yu AS, Yue L et al.. 2016. An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery.. Cell Stem Cell. 19(3):326-40.

Lin K, O'Brien KM, Trujillo C, Wang R, Wallach JB, Schnappinger D, Ehrt S. 2016. Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.. PLoS Pathog. 12(6):e1005675.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Resto YAlemán, Alsibaee A, Alzualde A et al.. 2016. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.. PLoS Pathog. 12(7):e1005763.

Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR et al.. 2016. Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.. PLoS Pathog. 12(12):e1006043.

2017

Xu W, DeJesus MA, Rücker N, Engelhart CA, Wright MG, Healy C, Lin K, Wang R, Park SWoong, Ioerger TR et al.. 2017. Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.. Antimicrob Agents Chemother. 61(12)

Xu W, DeJesus MA, Rücker N, Engelhart CA, Wright MG, Healy C, Lin K, Wang R, Park SWoong, Ioerger TR et al.. 2017. Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.. Antimicrob Agents Chemother. 61(12)

Botella H, Yang G, Ouerfelli O, Ehrt S, Nathan CF, Vaubourgeix J. 2017. Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis.. mBio. 8(5)

Ruecker N, Jansen R, Trujillo C, Puckett S, Jayachandran P, Piroli GG, Frizzell N, Molina H, Rhee KY, Ehrt S. 2017. Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.. Cell Chem Biol. 24(3):306-315.

Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt S. 2017. Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 114(11):E2225-E2232.

Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt S. 2017. Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 114(11):E2225-E2232.

Botella H, Vaubourgeix J, Lee MHee, Song N, Xu W, Makinoshima H, Glickman MS, Ehrt S. 2017. Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress.. EMBO J. 36(4):536-548.

Poran A, Nötzel C, Aly O, Mencia-Trinchant N, Harris CT, Guzman ML, Hassane DC, Elemento O, Kafsack BFC. 2017. Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites.. Nature. 551(7678):95-99.

2018

Oh S, Park Y, Engelhart CA, Wallach JB, Schnappinger D, Arora K, Manikkam M, Gac B, Wang H, Murgolo N et al.. 2018. Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.. J Med Chem. 61(22):9952-9965.

Wescott HH, Zuniga ES, Bajpai A, Trujillo C, Ehrt S, Schnappinger D, Roberts DM, Parish T. 2018. Identification of Enolase as the Target of 2-Aminothiazoles in .. Front Microbiol. 9:2542.

Ehrt S, Schnappinger D, Rhee KY. 2018. Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.. Nat Rev Microbiol. 16(8):496-507.

Tiwari D, Park SWoong, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HPin, Engelhart CA et al.. 2018. Targeting protein biotinylation enhances tuberculosis chemotherapy.. Sci Transl Med. 10(438)

Tiwari D, Park SWoong, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HPin, Engelhart CA et al.. 2018. Targeting protein biotinylation enhances tuberculosis chemotherapy.. Sci Transl Med. 10(438)

Tiwari D, Park SWoong, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HPin, Engelhart CA et al.. 2018. Targeting protein biotinylation enhances tuberculosis chemotherapy.. Sci Transl Med. 10(438)

2019

Early J, Ollinger J, Darby C, Alling T, Mullen S, Casey A, Gold B, Ochoada J, Wiernicki T, Masquelin T et al.. 2019. Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis.. ACS Infect Dis. 5(2):272-280.

Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N et al.. 2019. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.. Nature. 571(7763):72-78.

Buter J, Cheng T-Y, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN et al.. 2019. Mycobacterium tuberculosis releases an antacid that remodels phagosomes.. Nat Chem Biol. 15(9):889-899.

Buter J, Cheng T-Y, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN et al.. 2019. Mycobacterium tuberculosis releases an antacid that remodels phagosomes.. Nat Chem Biol. 15(9):889-899.