Microbiology and Immunology

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2016

Yan W, Ding A, Kim H-J, Zheng H, Wei F, Ma X. 2016. Progranulin Controls Sepsis via C/EBPα-Regulated Il10 Transcription and Ubiquitin Ligase/Proteasome-Mediated Protein Degradation.. J Immunol. 197(8):3393-3405.

Chauhan R, Ravi J, Datta P, Chen T, Schnappinger D, Bassler KE, Balázsi G, Gennaro MLaura. 2016. Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis.. Nat Commun. 7:11062.

Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR et al.. 2016. Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.. PLoS Pathog. 12(12):e1006043.

Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR et al.. 2016. Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.. PLoS Pathog. 12(12):e1006043.

2015

Seehus CR, Aliahmad P, de la Torre B, Iliev ID, Spurka L, Funari VA, Kaye J. 2015. The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor.. Nat Immunol. 16(6):599-608.

Ukaegbu UE, Deitsch KW. 2015. The Emerging Role for RNA Polymerase II in Regulating Virulence Gene Expression in Malaria Parasites.. PLoS Pathog. 11(7):e1004926.

Dai R, Geders TW, Liu F, Park SWoong, Schnappinger D, Aldrich CC, Finzel BC. 2015. Fragment-based exploration of binding site flexibility in Mycobacterium tuberculosis BioA.. J Med Chem. 58(13):5208-17.

de Sena-Tomás C, Yu EYoung, Calzada A, Holloman WK, Lue NF, Pérez-Martín J. 2015. Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres.. Nucleic Acids Res. 43(4):2138-51.

Sanders RW, van Gils MJ, Derking R, Sok D, Ketas TJ, Burger JA, Ozorowski G, Cupo A, Simonich C, Goo L et al.. 2015. HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers.. Science. 349(6244):aac4223.

Sanders RW, van Gils MJ, Derking R, Sok D, Ketas TJ, Burger JA, Ozorowski G, Cupo A, Simonich C, Goo L et al.. 2015. HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers.. Science. 349(6244):aac4223.

Sanders RW, van Gils MJ, Derking R, Sok D, Ketas TJ, Burger JA, Ozorowski G, Cupo A, Simonich C, Goo L et al.. 2015. HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers.. Science. 349(6244):aac4223.

Zhao N, Sun M, Burns-Huang K, Jiang X, Ling Y, Darby C, Ehrt S, Liu G, Nathan C. 2015. Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis.. PLoS One. 10(5):e0126211.

Ringe RP, Yasmeen A, Ozorowski G, Go EP, Pritchard LK, Guttman M, Ketas TA, Cottrell CA, Wilson IA, Sanders RW et al.. 2015. Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers.. J Virol. 89(23):12189-210.

Vaubourgeix J, Lin G, Dhar N, Chenouard N, Jiang X, Botella H, Lupoli T, Mariani O, Yang G, Ouerfelli O et al.. 2015. Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells.. Cell Host Microbe. 17(2):178-90.

Park SWoong, Casalena DE, Wilson DJ, Dai R, Nag PP, Liu F, Boyce JP, Bittker JA, Schreiber SL, Finzel BC et al.. 2015. Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.. Chem Biol. 22(1):76-86.

Zhao N, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED et al.. 2015. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.. ACS Chem Biol. 10(2):364-71.

Bockman MR, Kalinda AS, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, Dawadi S, Nandakumar M, Rhee KY, Schnappinger D et al.. 2015. Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.. J Med Chem. 58(18):7349-7369.

Bockman MR, Kalinda AS, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, Dawadi S, Nandakumar M, Rhee KY, Schnappinger D et al.. 2015. Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.. J Med Chem. 58(18):7349-7369.

Garg A, Wesolowski D, Alonso D, Deitsch KW, Ben Mamoun C, Altman S. 2015. Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum.. Proc Natl Acad Sci U S A. 112(38):11935-40.

Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LPedro Sori, Rhee K, Ehrt S. 2015. Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.. Nat Commun. 6:7912.

Ukaegbu UE, Zhang X, Heinberg AR, Wele M, Chen Q, Deitsch KW. 2015. A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum.. PLoS Genet. 11(5):e1005234.

2014

Sinha A, Hughes KR, Modrzynska KK, Otto TD, Pfander C, Dickens NJ, Religa AA, Bushell E, Graham AL, Cameron R et al.. 2014. A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium.. Nature. 507(7491):253-257.

Sander AF, Lavstsen T, Rask TS, Lisby M, Salanti A, Fordyce SL, Jespersen JS, Carter R, Deitsch K, Theander TG et al.. 2014. DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families.. Nucleic Acids Res. 42(4):2270-81.

Kirkman L, Lawrence EA, Deitsch K. 2014. Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity.. Nucleic Acids Res. 42(1):370-9.

Torgbor C, Awuah P, Deitsch K, Kalantari P, Duca KA, Thorley-Lawson DA. 2014. A multifactorial role for P. falciparum malaria in endemic Burkitt's lymphoma pathogenesis.. PLoS Pathog. 10(5):e1004170.