Microbiology and Immunology

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2026

Liu Q, Engelhart CA, Wallach JB, Ge P, Wong T-Y, Orimoloye MO, Rodriguez S, Jayasinghe YP, Ronning DR, Dartois V et al.. 2026. Design, Synthesis and Biological Evaluation of Potent Piperazine-Based BioA Inhibitors Targeting Biotin Biosynthesis in Mycobacterium tuberculosis.. J Med Chem.

Warrier T, Martinez-Hoyos M, de Francisco EPorras, Lenaerts AJ, Gruppo V, Robertson GT, Li K, Aubé J, Bonnet I, Jiang X et al.. 2026. Diaryl-Aminoindazole with Extensive In Vitro Mycobactericidal Activity Dependent on Exposure to Reactive Nitrogen Species.. ACS Infect Dis.

Klevorn T, Brown C, Hardy CD, Cuthbert BJ, Spencer A, Jinich A, Chan L, Angala SK, Manzer J, Mendoza J et al.. 2026. A periplasmic protein complex mediates arabinofuranosyltransferase activity and intrinsic drug resistance in Mycobacterium tuberculosis.. Sci Adv. 12(14):eaec5100.

Khonde LPeguy, Peton N, Masike K, Valentine T, Zindo F, Fienberg S, Omollo C, Njoroge M, Vallini F, Tammaro C et al.. 2026. Structure-Activity relationship and optimization of drug-like properties of antituberculosis 3-(4,4-dimethyl-1,4-azasilinane)methylpyrazole MmpL3 inhibitors.. Eur J Med Chem. 312:118841.

2025

Yang Z, Zhang L, Ottavi S, Geri JB, Perkowski A, Jiang X, Pfau D, Bryk R, Aubé J, Zimmerman M et al.. 2025. ACOD1-mediated lysosomal membrane permeabilization contributes to Mycobacterium tuberculosis-induced macrophage death.. Proc Natl Acad Sci U S A. 122(12):e2425309122.

Mishra S, Singh PRanjan, Hu X, Lopez-Quezada L, Jinich A, Jahn R, Geurts L, Shen N, DeJesus MA, Hartman T et al.. 2025. Candidate transmission survival genome of Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 122(10):e2425981122.

Ames L, Allen R, Boshoff HIM, Cleghorn LAT, Engelhart CA, Schnappinger D, Parish T. 2025. Common Biological Properties of Mycobacterium tuberculosis MmpL3 Inhibitors.. ACS Infect Dis.

Ames L, Allen R, Boshoff HIM, Cleghorn LAT, Engelhart CA, Schnappinger D, Parish T. 2025. Common Biological Properties of Mycobacterium tuberculosis MmpL3 Inhibitors.. ACS Infect Dis.

Palme PR, Grover S, Abdelaziz R, Mann L, Kany AM, Ouologuem L, Bartel K, Sonnenkalb L, Reiling N, Hirsch AKH et al.. 2025. Design, Synthesis, and Biological Evaluation of Mono- and Diamino-Substituted Squaramide Derivatives as Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthase.. J Med Chem.

Ohara K, Assaad MAl, McNulty SN, Alnajar H, Sboner A, Wilkes DC, He F, Xiang JZhaoying, Mathew S, Elemento O et al.. 2025. Detection of rare and novel gene fusions in patients with diffuse glioma: An institutional retrospective study.. J Neuropathol Exp Neurol. 84(3):269-271.

Ohara K, Assaad MAl, McNulty SN, Alnajar H, Sboner A, Wilkes DC, He F, Xiang JZhaoying, Mathew S, Elemento O et al.. 2025. Detection of rare and novel gene fusions in patients with diffuse glioma: An institutional retrospective study.. J Neuropathol Exp Neurol. 84(3):269-271.

Dupnik KM, Dorvil N, Ward M, Rivera V, Apollon A, Dumont E, Sued O, Pape JW, Koenig SP. 2025. Histoplasma capsulatum Not Detected in People with HIV and Systemic Symptoms in Port-au-Prince, Haiti.. AIDS Res Hum Retroviruses.

Zhou W, Zhou JZ, Ahmed A, Kim MJoon, Guo C-J, Sonnenberg GF. 2025. ILC3s sense gut microbiota through STING to initiate immune tolerance.. Immunity. 58(7):1762-1777.e7.

Johnson WC, Alivisatos A, Smith TC, Van N, Soni V, Wallach JB, Clark NA, Fitzgerald TA, Whiteley JJ, Tan S et al.. 2025. Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action.. Cell Syst. :101348.

Johnson WC, Alivisatos A, Smith TC, Van N, Soni V, Wallach JB, Clark NA, Fitzgerald TA, Whiteley JJ, Tan S et al.. 2025. Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action.. Cell Syst. :101348.

Johnson WC, Alivisatos A, Smith TC, Van N, Soni V, Wallach JB, Clark NA, Fitzgerald TA, Whiteley JJ, Tan S et al.. 2025. Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action.. Cell Syst. :101348.

Howlader MJ, Ambler WG, Chalasani MLatha S, Rathod A, Seltzer ES, Sim JHyun, Shin J, Schwartz N, Shipman WD, Dasoveanu DC et al.. 2025. Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses.. J Clin Invest. 135(12)

Liu Q, Engelhart CA, Wallach JB, Tiwari D, Ge P, Manna A, Panda S, McCue WM, Wong T-Y, Sharma S et al.. 2025. Metabolically Stable Adenylation Inhibitors of Biotin Protein Ligase as Antibacterial Agents.. J Med Chem. 68(3):3065-3087.

Zhang M, Allen R, Ames L, Engelhart CA, Quach D, Lv X, Xiao G, Wang H, Wang J, Zhou L et al.. 2025. Microbiological evidence for the trisubstituted benzimidazoles targeting MmpL3 in Mycobacterium tuberculosis.. Antimicrob Agents Chemother. :e0036825.

Zhang M, Allen R, Ames L, Engelhart CA, Quach D, Lv X, Xiao G, Wang H, Wang J, Zhou L et al.. 2025. Microbiological evidence for the trisubstituted benzimidazoles targeting MmpL3 in Mycobacterium tuberculosis.. Antimicrob Agents Chemother. :e0036825.

Iliev ID, J Blander M, Collins N, Guo C-J, Longman RS, Sonnenberg GF, Zeng MY, Artis D. 2025. Microbiota-mediated mechanisms of mucosal immunity across the lifespan.. Nat Immunol.

Jinich A, Zaveri A, DeJesus MA, Spencer A, Almada-Monter R, Flores-Bautista E, Smith CM, Sassetti CM, Rock JM, Ehrt S et al.. 2025. The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB): A Large-Scale Guide to Genetic Conditional Essentiality.. Mol Microbiol. 124(1):91-101.

Caniels TG, Prabhakaran M, Ozorowski G, MacPhee KJ, Wu W, van der Straten K, Agrawal S, Derking R, Reiss EIMM, Millard K et al.. 2025. Precise targeting of HIV broadly neutralizing antibody precursors in humans.. Science. 389(6759):eadv5572.

Caniels TG, Prabhakaran M, Ozorowski G, MacPhee KJ, Wu W, van der Straten K, Agrawal S, Derking R, Reiss EIMM, Millard K et al.. 2025. Precise targeting of HIV broadly neutralizing antibody precursors in humans.. Science. 389(6759):eadv5572.

Xu A, Ayoub S, Zhang H, Wu Y, Rau M, Ma X. 2025. Regulatory T Cells in Invasive Breast Cancer: Prognosis, Mechanisms and Therapy.. Cancers (Basel). 17(19)