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A popular engagement at the ends.

TitleA popular engagement at the ends.
Publication TypeJournal Article
Year of Publication2013
AuthorsLue NF, Yu EYoung, Lei M
JournalNat Struct Mol Biol
Volume20
Issue1
Pagination10-2
Date Published2013 Jan
ISSN1545-9985
KeywordsAnimals, Protein Folding, RNA Interference, RNA, Small Interfering, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Telomerase, Telomere-Binding Proteins
Abstract

Three recent studies converged on a specific protein-protein interface between TPP1 and telomerase as being crucial for the regulation of both telomerase recruitment and processivity in mammalian cells. An equivalent interaction appears to exist in budding yeast, making this a nearly universal means of telomerase regulation.

DOI10.1038/nsmb.2483
Alternate JournalNat Struct Mol Biol
PubMed ID23288360
PubMed Central IDPMC5560596
Grant ListR01 GM062631 / GM / NIGMS NIH HHS / United States

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