Title | Plasticity of telomere maintenance mechanisms in yeast. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Lue NF |
Journal | Trends Biochem Sci |
Volume | 35 |
Issue | 1 |
Pagination | 8-17 |
Date Published | 2010 Jan |
ISSN | 0968-0004 |
Keywords | Chromosomal Proteins, Non-Histone, Saccharomycetales, Telomerase, Telomere |
Abstract | Telomeres, the nucleoprotein structures located at linear eukaryotic chromosomal termini, are essential for chromosome stability and are maintained by the special reverse transcriptase named telomerase. In the Saccharomycotina subphylum of budding yeast, telomere repeat sequences and binding factors, as well as telomerase components, are exceptionally diverse and distinct from those found in other eukaryotes. In this survey, I report a comparative analysis of the domain structures of telomere and telomerase-related factors made possible by the recent sequencing of multiple yeast genomes. This analysis revealed both conserved and variable aspects of telomere maintenance. Based on these findings, I propose a plausible series of evolutionary events in budding yeast to account for its exceptional telomere structural divergence. |
DOI | 10.1016/j.tibs.2009.08.006 |
Alternate Journal | Trends Biochem Sci |
PubMed ID | 19846312 |
PubMed Central ID | PMC2818170 |
Grant List | GM062631 / GM / NIGMS NIH HHS / United States GM069507 / GM / NIGMS NIH HHS / United States R01 GM069507-04 / GM / NIGMS NIH HHS / United States R01 GM062631 / GM / NIGMS NIH HHS / United States R01 GM069507 / GM / NIGMS NIH HHS / United States R01 GM062631-08 / GM / NIGMS NIH HHS / United States |
Submitted by jom4013 on December 3, 2020 - 4:17pm