Plasticity of telomere maintenance mechanisms in yeast.

TitlePlasticity of telomere maintenance mechanisms in yeast.
Publication TypeJournal Article
Year of Publication2010
AuthorsLue NF
JournalTrends Biochem Sci
Volume35
Issue1
Pagination8-17
Date Published2010 Jan
ISSN0968-0004
KeywordsChromosomal Proteins, Non-Histone, Saccharomycetales, Telomerase, Telomere
Abstract

Telomeres, the nucleoprotein structures located at linear eukaryotic chromosomal termini, are essential for chromosome stability and are maintained by the special reverse transcriptase named telomerase. In the Saccharomycotina subphylum of budding yeast, telomere repeat sequences and binding factors, as well as telomerase components, are exceptionally diverse and distinct from those found in other eukaryotes. In this survey, I report a comparative analysis of the domain structures of telomere and telomerase-related factors made possible by the recent sequencing of multiple yeast genomes. This analysis revealed both conserved and variable aspects of telomere maintenance. Based on these findings, I propose a plausible series of evolutionary events in budding yeast to account for its exceptional telomere structural divergence.

DOI10.1016/j.tibs.2009.08.006
Alternate JournalTrends Biochem Sci
PubMed ID19846312
PubMed Central IDPMC2818170
Grant ListGM062631 / GM / NIGMS NIH HHS / United States
GM069507 / GM / NIGMS NIH HHS / United States
R01 GM069507-04 / GM / NIGMS NIH HHS / United States
R01 GM062631 / GM / NIGMS NIH HHS / United States
R01 GM069507 / GM / NIGMS NIH HHS / United States
R01 GM062631-08 / GM / NIGMS NIH HHS / United States

Weill Cornell Medicine Microbiology and Immunology 1300 York Avenue, Box 62 New York, NY 10065 Phone: (212) 746-6505 Fax: (212) 746-8587