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Plasmodium falciparum STEVOR proteins impact erythrocyte mechanical properties.

TitlePlasmodium falciparum STEVOR proteins impact erythrocyte mechanical properties.
Publication TypeJournal Article
Year of Publication2012
AuthorsSanyal S, Egée S, Bouyer G, Perrot S, Safeukui I, Bischoff E, Buffet P, Deitsch KW, Mercereau-Puijalon O, David PH, Templeton TJ, Lavazec C
JournalBlood
Volume119
Issue2
Paginatione1-8
Date Published2012 Jan 12
ISSN1528-0020
KeywordsAntigens, Protozoan, Cells, Cultured, Erythrocyte Membrane, Erythrocytes, Fluorescent Antibody Technique, Indirect, Humans, Malaria, Falciparum, Plasmodium falciparum, Real-Time Polymerase Chain Reaction, RNA, Messenger
Abstract

Infection of erythrocytes with the human malaria parasite, Plasmodium falciparum, results in dramatic changes to the host cell structure and morphology. The predicted functional localization of the STEVOR proteins at the erythrocyte surface suggests that they may be involved in parasite-induced modifications of the erythrocyte membrane during parasite development. To address the biologic function of STEVOR proteins, we subjected a panel of stevor transgenic parasites and wild-type clonal lines exhibiting different expression levels for stevor genes to functional assays exploring parasite-induced modifications of the erythrocyte membrane. Using this approach, we show that stevor expression impacts deformability of the erythrocyte membrane. This process may facilitate parasite sequestration in deep tissue vasculature.

DOI10.1182/blood-2011-08-370734
Alternate JournalBlood
PubMed ID22106347
PubMed Central IDPMC3257022
Grant ListP01 HL078826 / HL / NHLBI NIH HHS / United States
R01 AI080754 / AI / NIAID NIH HHS / United States
1R01AI080754-01A1 / AI / NIAID NIH HHS / United States
5P01HL078826-06 / HL / NHLBI NIH HHS / United States

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