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PCR/LDR/universal array platforms for the diagnosis of infectious disease.

TitlePCR/LDR/universal array platforms for the diagnosis of infectious disease.
Publication TypeJournal Article
Year of Publication2010
AuthorsPingle M, Rundell M, Das S, Golightly LM, Barany F
JournalMethods Mol Biol
Volume632
Pagination141-57
Date Published2010
ISSN1940-6029
KeywordsCommunicable Diseases, Humans, Ligases, Nucleic Acid Hybridization, Oligonucleotide Array Sequence Analysis, Oligonucleotides, Point-of-Care Systems, Polymerase Chain Reaction, Printing, Quality Control
Abstract

Infectious diseases account for between 14 and 17 million deaths worldwide each year. Accurate and rapid diagnosis of bacterial, fungal, viral, and parasitic infections is therefore essential to reduce the morbidity and mortality associated with these diseases. Classical microbiological and serological methods have long served as the gold standard for diagnosis but are increasingly being replaced by molecular diagnostic methods that demonstrate increased sensitivity and specificity and provide an identification of the etiologic agent in a shorter period of time. PCR/LDR coupled with universal array detection provides a highly sensitive and specific platform for the detection and identification of bacterial and viral infections.

DOI10.1007/978-1-60761-663-4_9
Alternate JournalMethods Mol. Biol.
PubMed ID20217576
Grant ListP01-CA65930 / CA / NCI NIH HHS / United States
UC1-AI062579 / AI / NIAID NIH HHS / United States

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