Mitotic Heteroallelic and Sister Chromatid Recombination.

TitleMitotic Heteroallelic and Sister Chromatid Recombination.
Publication TypeJournal Article
Year of Publication2026
AuthorsSutherland JH, Holloman WK
JournalMethods Mol Biol
Volume3050
Pagination255-262
Date Published2026
ISSN1940-6029
KeywordsAlleles, Chromatids, DNA Breaks, Double-Stranded, DNA Repair, Homologous Recombination, Mitosis, Recombination, Genetic, Recombinational DNA Repair, Sister Chromatid Exchange
Abstract

Homologous recombination is a high-fidelity DNA repair mechanism used by mitotic cells to repair double-strand breaks and other types of DNA damage. This process preferentially uses a sister chromatid as a template, ensuring error-free repair, but can also use a homologous sequence on another chromosome. Here, methods are described that can be used to measure recombination between sister chromatids or homologs.

DOI10.1007/978-1-0716-5364-7_24
Alternate JournalMethods Mol Biol
PubMed ID42681049
PubMed Central ID1205144

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