|Title||A new twist on RNA helicases: DExH/D box proteins as RNPases.|
|Publication Type||Journal Article|
|Year of Publication||2001|
|Journal||Nat Struct Biol|
|Date Published||2001 Feb|
|Keywords||Adenosine Triphosphatases, Amino Acid Motifs, Animals, Base Sequence, Ribonucleoproteins, RNA, RNA Helicases, RNA Splicing, RNA-Binding Proteins, Spliceosomes|
DExH/D box proteins are required for the major transactions of RNA, including mRNA synthesis, pre-mRNA splicing, ribosome biogenesis, translation and RNA decay. In the popular imagination, DExH/D box proteins have become synonymous with 'RNA helicases', which are enzymes that unwind duplex RNAs in concert with the hydrolysis of nucleoside triphosphates (NTPs). But all DExH/D box proteins may not be RNA helicases and the energy of NTP hydrolysis by DExH/D box proteins may be harnessed for other purposes. Cellular RNAs are associated with proteins, often in large ribonucleoprotein (RNP) complexes. This review focuses on recent progress suggesting a role for DExH/D box proteins as 'RNPases' that use chemical energy to remodel the interactions of RNA and proteins.
|Alternate Journal||Nat. Struct. Biol.|