| Title | A new twist on RNA helicases: DExH/D box proteins as RNPases. |
| Publication Type | Journal Article |
| Year of Publication | 2001 |
| Authors | Schwer B |
| Journal | Nat Struct Biol |
| Volume | 8 |
| Issue | 2 |
| Pagination | 113-6 |
| Date Published | 2001 Feb |
| ISSN | 1072-8368 |
| Keywords | Adenosine Triphosphatases, Amino Acid Motifs, Animals, Base Sequence, Ribonucleoproteins, RNA, RNA Helicases, RNA Splicing, RNA-Binding Proteins, Spliceosomes |
| Abstract | DExH/D box proteins are required for the major transactions of RNA, including mRNA synthesis, pre-mRNA splicing, ribosome biogenesis, translation and RNA decay. In the popular imagination, DExH/D box proteins have become synonymous with 'RNA helicases', which are enzymes that unwind duplex RNAs in concert with the hydrolysis of nucleoside triphosphates (NTPs). But all DExH/D box proteins may not be RNA helicases and the energy of NTP hydrolysis by DExH/D box proteins may be harnessed for other purposes. Cellular RNAs are associated with proteins, often in large ribonucleoprotein (RNP) complexes. This review focuses on recent progress suggesting a role for DExH/D box proteins as 'RNPases' that use chemical energy to remodel the interactions of RNA and proteins. |
| DOI | 10.1038/84091 |
| Alternate Journal | Nat. Struct. Biol. |
| PubMed ID | 11175897 |
Submitted by mam2155 on March 24, 2014 - 4:20pm