Title | The mycobiota: interactions between commensal fungi and the host immune system. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Underhill DM, Iliev ID |
Journal | Nat Rev Immunol |
Volume | 14 |
Issue | 6 |
Pagination | 405-16 |
Date Published | 2014 Jun |
ISSN | 1474-1741 |
Keywords | Animals, Fungi, Host-Pathogen Interactions, Humans, Immune System, Mice, Microbiota, Mycoses, Signal Transduction, Symbiosis |
Abstract | The body is host to a wide variety of microbial communities from which the immune system protects us and that are important for the normal development of the immune system and for the maintenance of healthy tissues and physiological processes. Investigators have mostly focused on the bacterial members of these communities, but fungi are increasingly being recognized to have a role in defining these communities and to interact with immune cells. In this Review, we discuss what is currently known about the makeup of fungal communities in the body and the features of the immune system that are particularly important for interacting with fungi at these sites. |
DOI | 10.1038/nri3684 |
Alternate Journal | Nat. Rev. Immunol. |
PubMed ID | 24854590 |
PubMed Central ID | PMC4332855 |
Grant List | DK093426 / DK / NIDDK NIH HHS / United States DK098310 / DK / NIDDK NIH HHS / United States K99 DK098310 / DK / NIDDK NIH HHS / United States R01 DK093426 / DK / NIDDK NIH HHS / United States |
Submitted by alp2017 on April 1, 2016 - 3:40pm