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Microarray expression profiling: analysis and applications.

TitleMicroarray expression profiling: analysis and applications.
Publication TypeJournal Article
Year of Publication2003
AuthorsXiang Z, Yang Y, Ma X, Ding W
JournalCurr Opin Drug Discov Devel
Volume6
Issue3
Pagination384-95
Date Published2003 May
ISSN1367-6733
KeywordsDatabases, Genetic, Gene Expression Profiling, Gene Expression Regulation, Oligonucleotide Array Sequence Analysis
Abstract

Recent advances in the technology of massive parallel gene expression profiling using microarrays are revolutionizing biomedical research and pharmacological discovery. These new and powerful tools allow researchers to examine the dynamics of a whole biological system by simultaneously interrogating the expression of tens of thousands of genes. This article will review the various bioinformatics and statistical methods commonly used to analyze the enormous amounts of data generated by this technology. The objective of these analyses is to reliably extract important biological information from carefully designed and controlled microarray experiments, and to organize the information in ways that reveal structured and coordinated physiological processes and key components controlling the biological responses studied. The major applications of the microarray technology, recently used to address a variety of biological questions of interest to scientists and clinicians in academia, healthcare and the pharmaceutical industry, will also be presented.

Alternate JournalCurr Opin Drug Discov Devel
PubMed ID12833672
Grant ListAI45899 / AI / NIAID NIH HHS / United States
CA79772 / CA / NCI NIH HHS / United States
HG0008 / HG / NHGRI NIH HHS / United States

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