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Metabolic regulation of sexual commitment in Plasmodium falciparum.

TitleMetabolic regulation of sexual commitment in Plasmodium falciparum.
Publication TypeJournal Article
Year of Publication2020
AuthorsNeveu G, Beri D, Kafsack BFc
JournalCurr Opin Microbiol
Volume58
Pagination93-98
Date Published2020 Oct 11
ISSN1879-0364
Abstract

For malaria parasites regulating sexual commitment, the frequency with which asexual bloodstream forms differentiate into non-replicative male and female gametocytes, is critical because asexual replication is required to maintain a persistent infection of the human host while gametocytes are essential for infection of the mosquito vector and transmission. Here, we describe recent advances in understanding of the regulatory mechanisms controlling this key developmental decision. These include new insights into the mechanistic roles of the transcriptional master switch AP2-G and the epigenetic modulator GDV1, as well as the identification of defined metabolic signals that modulate their activity. Many of these metabolites are linked to parasite phospholipid biogenesis and we propose a model linking this pathway to the epigenetic regulation underlying sexual commitment in P. falciparum.

DOI10.1016/j.mib.2020.09.004
Alternate JournalCurr Opin Microbiol
PubMed ID33053503

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