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Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites.

TitleMechanisms underlying mutually exclusive expression of virulence genes by malaria parasites.
Publication TypeJournal Article
Year of Publication2007
AuthorsDzikowski R, Li F, Amulic B, Eisberg A, Frank M, Patel S, Wellems TE, Deitsch KW
JournalEMBO Rep
Volume8
Issue10
Pagination959-65
Date Published2007 Oct
ISSN1469-221X
KeywordsAnimals, Gene Silencing, In Situ Hybridization, Malaria, Falciparum, Plasmodium falciparum, Promoter Regions, Genetic, Protozoan Proteins, Reverse Transcriptase Polymerase Chain Reaction, Transcription, Genetic, Virulence
Abstract

A fundamental yet poorly understood aspect of gene regulation in eukaryotic organisms is the mechanisms that control allelic exclusion and mutually exclusive gene expression. In the malaria parasite Plasmodium falciparum, this process regulates expression of the var gene family--a large, hypervariable repertoire of genes that are responsible for the ability of the parasite to evade the host immune system and for pathogenesis of the disease. A central problem in understanding this process concerns the mechanisms that limit expression to a single gene at a time. Here, we describe results that provide information on the mechanisms that control silencing and single gene expression and differentiate between several models that have recently been proposed. The results provide the first evidence, to our knowledge, supporting the existence of a postulated var-specific, subnuclear expression site and also reinforce the conclusion that var gene regulation is based on cooperative interactions between the two promoters of each var gene.

DOI10.1038/sj.embor.7401063
Alternate JournalEMBO Rep
PubMed ID17762879
PubMed Central IDPMC2002552
Grant ListR01 AI052390 / AI / NIAID NIH HHS / United States
T32 GM007739 / GM / NIGMS NIH HHS / United States

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