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Malaria virulence genes controlling expression through chromatin modification.

TitleMalaria virulence genes controlling expression through chromatin modification.
Publication TypeJournal Article
Year of Publication2005
AuthorsDeitsch KW
JournalCell
Volume121
Issue1
Pagination1-2
Date Published2005 Apr 08
ISSN0092-8674
KeywordsAnimals, Antigenic Variation, Cell Compartmentation, Cell Nucleus, Chromatin Assembly and Disassembly, Gene Expression Regulation, Gene Silencing, Genes, Protozoan, Heterochromatin, Malaria, Falciparum, Plasmids, Plasmodium falciparum, Telomere, Virulence
Abstract

Mutually exclusive expression within the var gene family of the malaria parasite Plasmodium falciparum is important for parasite survival and virulence. In this issue of Cell, Duraisingh et al. and Freitas-Junior et al. provide evidence for the role of Sir2-dependent alterations in chromatin structure and changes in subnuclear chromatin localization in regulating var gene expression (Duraisingh et al., 2005; Freitas-Junior et al., 2005).

DOI10.1016/j.cell.2005.03.019
Alternate JournalCell
PubMed ID15820670

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