Malaria virulence genes controlling expression through chromatin modification.

TitleMalaria virulence genes controlling expression through chromatin modification.
Publication TypeJournal Article
Year of Publication2005
AuthorsDeitsch KW
Date Published2005 Apr 08
KeywordsAnimals, Antigenic Variation, Cell Compartmentation, Cell Nucleus, Chromatin Assembly and Disassembly, Gene Expression Regulation, Gene Silencing, Genes, Protozoan, Heterochromatin, Malaria, Falciparum, Plasmids, Plasmodium falciparum, Telomere, Virulence

Mutually exclusive expression within the var gene family of the malaria parasite Plasmodium falciparum is important for parasite survival and virulence. In this issue of Cell, Duraisingh et al. and Freitas-Junior et al. provide evidence for the role of Sir2-dependent alterations in chromatin structure and changes in subnuclear chromatin localization in regulating var gene expression (Duraisingh et al., 2005; Freitas-Junior et al., 2005).

Alternate JournalCell
PubMed ID15820670

Weill Cornell Medicine Microbiology and Immunology 1300 York Avenue, Box 62 New York, NY 10065 Phone: (212) 746-6505 Fax: (212) 746-8587