Submitted by mam2155 on March 24, 2014 - 4:11pm
| Title | Malaria virulence genes controlling expression through chromatin modification. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Deitsch KW |
| Journal | Cell |
| Volume | 121 |
| Issue | 1 |
| Pagination | 1-2 |
| Date Published | 2005 Apr 08 |
| ISSN | 0092-8674 |
| Keywords | Animals, Antigenic Variation, Cell Compartmentation, Cell Nucleus, Chromatin Assembly and Disassembly, Gene Expression Regulation, Gene Silencing, Genes, Protozoan, Heterochromatin, Malaria, Falciparum, Plasmids, Plasmodium falciparum, Telomere, Virulence |
| Abstract | Mutually exclusive expression within the var gene family of the malaria parasite Plasmodium falciparum is important for parasite survival and virulence. In this issue of Cell, Duraisingh et al. and Freitas-Junior et al. provide evidence for the role of Sir2-dependent alterations in chromatin structure and changes in subnuclear chromatin localization in regulating var gene expression (Duraisingh et al., 2005; Freitas-Junior et al., 2005). |
| DOI | 10.1016/j.cell.2005.03.019 |
| Alternate Journal | Cell |
| PubMed ID | 15820670 |