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Malaria. Cooperative silencing elements in var genes.

TitleMalaria. Cooperative silencing elements in var genes.
Publication TypeJournal Article
Year of Publication2001
AuthorsDeitsch KW, Calderwood MS, Wellems TE
JournalNature
Volume412
Issue6850
Pagination875-6
Date Published2001 Aug 30
ISSN0028-0836
KeywordsAnimals, Gene Silencing, Genes, Protozoan, Introns, Plasmodium falciparum, Promoter Regions, Genetic, Protozoan Proteins, Regulatory Sequences, Nucleic Acid, S Phase
Abstract

Each Plasmodium falciparum malaria parasite carries about 50 var genes from a diverse family that encode variable adhesion proteins on the infected red blood cells of the host, but individual parasites single out just one var gene for expression and silence all the others. Here we show that this silencing is established during the DNA-synthesis phase (S phase) of the cell cycle and that it depends on the cooperative interaction between two elements in separate control regions of each var gene (the 5'-flanking region and the intron). This finding should help to clarify the mechanisms by which parasites coordinate the silencing and activation of var genes that are responsible for antigenic variation in malaria.

DOI10.1038/35091146
Alternate JournalNature
PubMed ID11528468

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