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Intra-cluster recombination and var transcription switches in the antigenic variation of Plasmodium falciparum.

TitleIntra-cluster recombination and var transcription switches in the antigenic variation of Plasmodium falciparum.
Publication TypeJournal Article
Year of Publication1999
AuthorsDeitsch KW, del Pinal A, Wellems TE
JournalMol Biochem Parasitol
Volume101
Issue1-2
Pagination107-16
Date Published1999 Jun 25
ISSN0166-6851
KeywordsAnimals, Antigenic Variation, Erythrocytes, Gene Expression Regulation, Genes, Protozoan, Genes, Switch, Multigene Family, Plasmodium falciparum, Promoter Regions, Genetic, Recombination, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Transcription, Genetic
Abstract

Antigenic variation and immune evasion by Plasmodium falciparum parasitized erythrocytes are mediated by expression switches among members of the multicopy var gene family. Here we describe a cluster of var genes on chromosome 12 that showed spontaneous recombination and switches in the transcription of individual genes. The transcription switches were not associated with sequence changes in promoter regions. Transfected episomes containing a luciferase reporter under control of a var promoter were expressed regardless of the transcriptional status of the endogenous promoter. The results suggest epigenetic regulation of P. falciparum var gene transcription that depends upon the local structure of chromatin and its associated proteins.

DOI10.1016/s0166-6851(99)00062-6
Alternate JournalMol Biochem Parasitol
PubMed ID10413047

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