Title | Interferon-γ and infectious diseases: Lessons and prospects. |
Publication Type | Journal Article |
Year of Publication | 2024 |
Authors | Casanova J-L, MacMicking JD, Nathan CF |
Journal | Science |
Volume | 384 |
Issue | 6693 |
Pagination | eadl2016 |
Date Published | 2024 Apr 19 |
ISSN | 1095-9203 |
Keywords | Communicable Diseases, Humans, Immunity, Interferon-gamma |
Abstract | Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from these diseases would benefit not just from new medicines and vaccines but also from a better understanding of what constitutes protective immunity. Among the major immune signals that mobilize host defense against infection is interferon-γ (IFN-γ), a protein secreted by lymphocytes. Forty years ago, IFN-γ was identified as a macrophage-activating factor, and, in recent years, there has been a resurgent interest in IFN-γ biology and its role in human defense. Here we assess the current understanding of IFN-γ, revisit its designation as an "interferon," and weigh its prospects as a therapeutic against globally pervasive microbial pathogens. |
DOI | 10.1126/science.adl2016 |
Alternate Journal | Science |
PubMed ID | 38635718 |
Grant List | R01 AI095983 / AI / NIAID NIH HHS / United States U19 AI162568 / AI / NIAID NIH HHS / United States UL1 TR001866 / TR / NCATS NIH HHS / United States R01 AI068041 / AI / NIAID NIH HHS / United States R01 AI108834 / AI / NIAID NIH HHS / United States |
Submitted by ljc4002 on August 21, 2025 - 1:32pm