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Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease.

TitleInnate lymphoid cell interactions with microbiota: implications for intestinal health and disease.
Publication TypeJournal Article
Year of Publication2012
AuthorsSonnenberg GF, Artis D
JournalImmunity
Volume37
Issue4
Pagination601-10
Date Published2012 Oct 19
ISSN1097-4180
KeywordsAnimals, Humans, Immunity, Innate, Intestinal Diseases, Intestines, Lymphoid Tissue, Metagenome
Abstract

The mammalian intestine harbors trillions of beneficial commensal bacteria that are essential for the development of the immune system and for maintenance of physiologic processes in multiple organs. However, numerous chronic infectious, inflammatory, and metabolic diseases in humans have been associated with alterations in the composition or localization of commensal bacteria that result in dysregulated host-commensal bacteria relationships. The mammalian immune system plays an essential role in regulating the acquisition, composition, and localization of commensal bacteria in the intestine. Emerging research has implicated innate lymphoid cells (ILCs) as a critical immune cell population that orchestrates some of these host-commensal bacteria relationships that can impact immunity, inflammation, and tissue homeostasis in the intestine. This review will discuss reciprocal interactions between intestinal commensal bacteria and ILCs in the context of health and disease.

DOI10.1016/j.immuni.2012.10.003
Alternate JournalImmunity
PubMed ID23084357
PubMed Central IDPMC3495160
Grant ListAI061570 / AI / NIAID NIH HHS / United States
AI074878 / AI / NIAID NIH HHS / United States
AI083480 / AI / NIAID NIH HHS / United States
AI087990 / AI / NIAID NIH HHS / United States
AI095466 / AI / NIAID NIH HHS / United States
AI095608 / AI / NIAID NIH HHS / United States
AI097333 / AI / NIAID NIH HHS / United States
DP5 OD012116 / OD / NIH HHS / United States
DP5OD012116 / OD / NIH HHS / United States
R01 AI061570 / AI / NIAID NIH HHS / United States
R01 AI074878 / AI / NIAID NIH HHS / United States
R01 AI095466 / AI / NIAID NIH HHS / United States
R01 AI097333 / AI / NIAID NIH HHS / United States
R01 AI102942 / AI / NIAID NIH HHS / United States
R21 AI083480 / AI / NIAID NIH HHS / United States
R21 AI087990 / AI / NIAID NIH HHS / United States
T32-AI055428 / AI / NIAID NIH HHS / United States
U01 AI095608 / AI / NIAID NIH HHS / United States

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