|The homologous recombination system of Ustilago maydis.
|Year of Publication
|Holloman WK, Schirawski J, Holliday R
|Fungal Genet Biol
|45 Suppl 1
|DNA Repair, Fungal Proteins, Meiosis, Rad51 Recombinase, Rad52 DNA Repair and Recombination Protein, Recombination, Genetic, Ustilago
Homologous recombination is a high fidelity, template-dependent process that is used in repair of damaged DNA, recovery of broken replication forks, and disjunction of homologous chromosomes in meiosis. Much of what is known about recombination genes and mechanisms comes from studies on baker's yeast. Ustilago maydis, a basidiomycete fungus, is distant evolutionarily from baker's yeast and so offers the possibility of gaining insight into recombination from an alternative perspective. Here we have surveyed the genome of U. maydis to determine the composition of its homologous recombination system. Compared to baker's yeast, there are fundamental differences in the function as well as in the repertoire of dedicated components. These include the use of a BRCA2 homolog and its modifier Dss1 rather than Rad52 as a mediator of Rad51, the presence of only a single Rad51 paralog, and the absence of Dmc1 and auxiliary meiotic proteins.
|Fungal Genet. Biol.
|PubMed Central ID
|GM42482 / GM / NIGMS NIH HHS / United States
GM79859 / GM / NIGMS NIH HHS / United States
R01 GM042482 / GM / NIGMS NIH HHS / United States
R01 GM042482-17 / GM / NIGMS NIH HHS / United States
R01 GM079859 / GM / NIGMS NIH HHS / United States
R01 GM079859-01A1 / GM / NIGMS NIH HHS / United States
Submitted by alp2017 on April 24, 2015 - 10:31am