Title | Evolving Linear Chromosomes and Telomeres: A C-Strand-Centric View. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Lue NF |
Journal | Trends Biochem Sci |
Volume | 43 |
Issue | 5 |
Pagination | 314-326 |
Date Published | 2018 05 |
ISSN | 0968-0004 |
Keywords | Chromosomes, Humans, Telomere, Telomere-Binding Proteins |
Abstract | Recent studies have resulted in deeper understanding of a variety of telomere maintenance mechanisms as well as plausible models of telomere evolution. Often overlooked in the discussion of telomere regulation and evolution is the synthesis of the DNA strand that bears the 5'-end (i.e., the C-strand). Herein, I describe a scenario for telomere evolution that more explicitly accounts for the evolution of the C-strand synthesis machinery. In this model, CTC1-STN1-TEN1 (CST), the G-strand-binding complex that regulates primase-Pol α-mediated C-strand synthesis, emerges as a pivotal player and evolutionary link. Itself arising from RPA, CST not only coordinates telomere synthesis, but also gives rise to the POT1-TPP1 complex, which became part of shelterin and regulates telomerase in G-strand elongation. |
DOI | 10.1016/j.tibs.2018.02.008 |
Alternate Journal | Trends Biochem Sci |
PubMed ID | 29550242 |
PubMed Central ID | PMC7392036 |
Grant List | R01 GM107287 / GM / NIGMS NIH HHS / United States |
Submitted by wcm_microbiolog... on November 9, 2018 - 11:48am