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Epigenetic memory at malaria virulence genes.

TitleEpigenetic memory at malaria virulence genes.
Publication TypeJournal Article
Year of Publication2007
AuthorsChookajorn T, Dzikowski R, Frank M, Li F, Jiwani AZ, Hartl DL, Deitsch KW
JournalProc Natl Acad Sci U S A
Volume104
Issue3
Pagination899-902
Date Published2007 Jan 16
ISSN0027-8424
KeywordsAnimals, Chromatin, Epigenesis, Genetic, Gene Expression Regulation, Histones, Malaria, Methylation, Plasmodium falciparum, Transcription, Genetic, Virulence
Abstract

During its red blood cell stage, the malaria parasite Plasmodium falciparum can switch its variant surface proteins (P. falciparum erythrocyte membrane protein 1) to evade the host immune response. The var gene family encodes P. falciparum erythrocyte membrane protein 1, different versions of which have unique binding specificities to various human endothelial surface molecules. Individual parasites each contain approximately 60 var genes at various locations within their chromosomes; however, parasite isolates contain different complements of var genes, thus, the gene family is enormous with a virtually unlimited number of members. A single var gene is expressed by each parasite in a mutually exclusive manner. We report that control of var gene transcription and antigenic variation is associated with a chromatin memory that includes methylation of histone H3 at lysine K9 as an epigenetic mark. We also discuss how gene transcription memory may affect the mechanism of pathogenesis and immune evasion.

DOI10.1073/pnas.0609084103
Alternate JournalProc Natl Acad Sci U S A
PubMed ID17209011
PubMed Central IDPMC1764221
Grant ListR01 AI052390 / AI / NIAID NIH HHS / United States
AI 52390 / AI / NIAID NIH HHS / United States

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