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Eating at the table of another: metabolomics of host-parasite interactions.

TitleEating at the table of another: metabolomics of host-parasite interactions.
Publication TypeJournal Article
Year of Publication2010
AuthorsKafsack BFC, LlinĂ¡s M
JournalCell Host Microbe
Volume7
Issue2
Pagination90-9
Date Published2010 Feb 18
ISSN1934-6069
KeywordsAnimals, Host-Parasite Interactions, Humans, Metabolomics, Parasites
Abstract

The application of metabolomics, the global analysis of metabolite levels, to the study of protozoan parasites has become an important tool for understanding the host-parasite relationship and holds promise for the development of direly needed therapeutics and improved diagnostics. Research advances over the past decade have opened the door for a systems biology approach to protozoan parasites with metabolomics, providing a crucial readout of metabolic activity. In this review, we highlight recent metabolomic approaches to protozoan parasites, including metabolite profiling, integration with genomics, transcription, and proteomic analysis, and the use of metabolic fingerprints for the diagnosis of parasitic infections.

DOI10.1016/j.chom.2010.01.008
Alternate JournalCell Host Microbe
PubMed ID20159614
PubMed Central IDPMC2825149
Grant ListDP2 OD001315 / OD / NIH HHS / United States
DP2 OD001315-01 / OD / NIH HHS / United States
P50 GM071508 / GM / NIGMS NIH HHS / United States
1DP2OD001315-01 / OD / NIH HHS / United States
/ / Howard Hughes Medical Institute / United States

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