For COVID-19 vaccine updates, please review our information guide. For patient eligibility and scheduling availability, please visit VaccineTogetherNY.org.

Differential production of interleukin 10 during human immunodeficiency virus infection.

TitleDifferential production of interleukin 10 during human immunodeficiency virus infection.
Publication TypeJournal Article
Year of Publication1996
AuthorsChehimi J, Ma X, Chouaib S, Zyad A, Nagashunmugam T, Wojcik L, Chehimi S, Nissim L, Frank I
JournalAIDS Res Hum Retroviruses
Volume12
Issue12
Pagination1141-9
Date Published1996 Aug 10
ISSN0889-2229
KeywordsCD4 Lymphocyte Count, HIV Infections, HIV-1, Humans, Interleukin-10, T-Lymphocyte Subsets, Th1 Cells, Th2 Cells
Abstract

Interleukin 10, a product of T and B cells and monocytes, displays many Th2-like properties through inhibition of Th1 cell functions. Interleukin 10 is thought to play a major role in the immune dysfunction seen in HIV-infected individuals. In this study, we evaluated in detail the production of IL-10 during HIV infection. Although the constitutive production of IL-10 did not differ in PBMCs from healthy donors and HIV-infected individuals, IL-10 was differentially produced in response to polyclonal activators. The overall plasma IL-10 levels were similar in 32 controls and 67 patients at different stages of the disease and receiving different antiretroviral drugs. However, patients with low CD4 T cell count (< 200/mm3) secreted approximately three-fold more IL-10 than did patients with high CD4 T cell count (> 500/mm3). Competitive/quantitative PCR revealed similar levels of mRNA expression in PBMCs from controls and HIV-infected individuals. In vitro HIV infection rapidly and transiently induced IL-10 production in PBMCs and monocytes, and the low level of endogenously secreted IL-10 failed to inhibit HIV replication in acutely infected monocytes. On the other hand, HIV infection of selected CD4+ T cell clones generated in a Th1- or Th2-like environment, differentially up-regulated IL-10 production, with significantly higher production by Th2 clones. Together, our data indicate that IL-10 production is more complex than previously thought, and may depend on several factors such as producer cells, nature of the stimuli, as well as viral isolates.

DOI10.1089/aid.1996.12.1141
Alternate JournalAIDS Res Hum Retroviruses
PubMed ID8844018
Grant ListAI 34758 / AI / NIAID NIH HHS / United States
DE 09569 / DE / NIDCR NIH HHS / United States

Weill Cornell Medicine Microbiology and Immunology 1300 York Avenue, Box 62 New York, NY 10065 Phone: (212) 746-6505 Fax: (212) 746-8587