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Microbiology and Immunology

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Control by cesium and intermediates of the citric acid cycle of extracellular ribonuclease and other enzymes involved in the assimilation of nitrogen.

TitleControl by cesium and intermediates of the citric acid cycle of extracellular ribonuclease and other enzymes involved in the assimilation of nitrogen.
Publication TypeJournal Article
Year of Publication1971
AuthorsHolloman WK, Dekker CA
JournalProc Natl Acad Sci U S A
Volume68
Issue9
Pagination2241-5
Date Published1971 Sep
ISSN0027-8424
Keywords6-Mercaptopurine, Ammonia, Cesium, Chlorides, Citrates, Citric Acid Cycle, Cycloheximide, Dactinomycin, Enzyme Induction, Fumarates, Fungi, Galactosidases, Glutarates, Histidine, Lyases, Malates, Methylamines, Nitrates, Nitrogen, Oxaloacetates, Oxidoreductases, Phenylalanine, Ribonucleases, Succinates, Sucrase, Xanthine Oxidase
Abstract

Synthesis of extracellular ribonuclease is induced in cell cultures of Ustilago sphaerogena that are starved for nitrogen and exposed to the gratuitous inducer, 6-mercaptopurine. Cesium, ammonium, or alkylammonium ion represses ribonuclease induction. Addition of citric-acid cycle intermediates to cesium ionrepressed cultures partially restores the rate of ribonuclease synthesis to the induced level. Enzymes involved in assimilation of nitrogen from different sources are also repressed by cesium ion and derepressed by intermediates from the citric acid cycle.

Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID5289382
PubMed Central IDPMC389393

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