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BRCA2-RAD51-DSS1 interplay examined from a microbial perspective.

TitleBRCA2-RAD51-DSS1 interplay examined from a microbial perspective.
Publication TypeJournal Article
Year of Publication2004
AuthorsKojic M, Holloman WK
JournalCell Cycle
Volume3
Issue3
Pagination247-8
Date Published2004 Mar
ISSN1538-4101
KeywordsAnimals, BRCA2 Protein, DNA Repair, DNA-Binding Proteins, Humans, Infection, Protein Binding, Rad51 Recombinase
Abstract

The tumor suppressor BRCA2 plays an essential role in the repair of double-strand DNA breaks by regulating the action of the RAD51 recombinase. The activity of BRCA2 is in turn governed by DSS1, a small acidic protein that appears to function as a necessary cofactor. A model fungal system that reproduces the BRCA2-RAD51 interaction offers the opportunity to understand the mechanism of DSS1 activation at the molecular level.

Alternate JournalCell Cycle
PubMed ID14726651

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