Submitted by alp2017 on April 24, 2015 - 10:35am
| Title | BRCA2-RAD51-DSS1 interplay examined from a microbial perspective. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Kojic M, Holloman WK |
| Journal | Cell Cycle |
| Volume | 3 |
| Issue | 3 |
| Pagination | 247-8 |
| Date Published | 2004 Mar |
| ISSN | 1538-4101 |
| Keywords | Animals, BRCA2 Protein, DNA Repair, DNA-Binding Proteins, Humans, Infection, Protein Binding, Rad51 Recombinase |
| Abstract | The tumor suppressor BRCA2 plays an essential role in the repair of double-strand DNA breaks by regulating the action of the RAD51 recombinase. The activity of BRCA2 is in turn governed by DSS1, a small acidic protein that appears to function as a necessary cofactor. A model fungal system that reproduces the BRCA2-RAD51 interaction offers the opportunity to understand the mechanism of DSS1 activation at the molecular level. |
| Alternate Journal | Cell Cycle |
| PubMed ID | 14726651 |