|Title||BRCA2-RAD51-DSS1 interplay examined from a microbial perspective.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Kojic M, Holloman WK|
|Date Published||2004 Mar|
|Keywords||Animals, BRCA2 Protein, DNA Repair, DNA-Binding Proteins, Humans, Infection, Protein Binding, Rad51 Recombinase|
The tumor suppressor BRCA2 plays an essential role in the repair of double-strand DNA breaks by regulating the action of the RAD51 recombinase. The activity of BRCA2 is in turn governed by DSS1, a small acidic protein that appears to function as a necessary cofactor. A model fungal system that reproduces the BRCA2-RAD51 interaction offers the opportunity to understand the mechanism of DSS1 activation at the molecular level.
|Alternate Journal||Cell Cycle|