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Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22.

TitleBorder patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22.
Publication TypeJournal Article
Year of Publication2011
AuthorsSonnenberg GF, Fouser LA, Artis D
JournalNat Immunol
Volume12
Issue5
Pagination383-90
Date Published2011 May
ISSN1529-2916
KeywordsAdaptive Immunity, Animals, Humans, Immunity, Innate, Inflammation, Interleukins, Intestines, Mice, Models, Animal, Receptors, Interleukin, Respiratory System, Signal Transduction, Skin
Abstract

The maintenance of barrier function at exposed surfaces of the mammalian body is essential for limiting exposure to environmental stimuli, preventing systemic dissemination of commensal and pathogenic microbes and retaining normal homeostasis of the entire body. Indeed, dysregulated barrier function is associated with many infectious and inflammatory diseases, including psoriasis, influenza, inflammatory bowel disease and human immunodeficiency virus, which collectively afflict millions of people worldwide. Studies have shown that interleukin 22 (IL-22) is expressed at barrier surfaces and that its expression is dysregulated in certain human diseases, which suggests a critical role in the maintenance of normal barrier homeostasis. Consistent with that, studies of mouse model systems have identified a critical role for signaling by IL-22 through its receptor (IL-22R) in the promotion of antimicrobial immunity, inflammation and tissue repair at barrier surfaces. In this review we will discuss how the expression of IL-22 and IL-22R is regulated, the functions of the IL-22-IL-22R pathway in regulating immunity, inflammation and tissue homeostasis, and the therapeutic potential of targeting this pathway in human disease.

DOI10.1038/ni.2025
Alternate JournalNat. Immunol.
PubMed ID21502992
Grant ListAI083480 / AI / NIAID NIH HHS / United States
AI087990 / AI / NIAID NIH HHS / United States
AI61570 / AI / NIAID NIH HHS / United States
AI74878 / AI / NIAID NIH HHS / United States
T32AI007532-08 / AI / NIAID NIH HHS / United States

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