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Apicomplexan perforin-like proteins.

TitleApicomplexan perforin-like proteins.
Publication TypeJournal Article
Year of Publication2010
AuthorsKafsack BFC, Carruthers VB
JournalCommun Integr Biol
Volume3
Issue1
Pagination18-23
Date Published2010 Jan
ISSN1942-0889
Abstract

Numerous perforin-like proteins are encoded in the genomes of apicomplexan parasites, where they are expressed in various life-cycle stages and play critical roles in pathogenesis and lifecycle progression. These ApiPLPs are characterized by the presence of a MACPF domain, responsible for pore-formation in target membranes in a number of systems, including many bacterial pathogens and effector cells of the immune response. ApiPLP MACPF domains maintain the critical structural elements but are often present in new and intriguing domain arrangements. Recent work in Toxoplasma and Plasmodium has shown that ApiPLPs are important for breaching membranes during parasite egress and cell traversal. Here we present an overview of this important protein family from a structural, functional and phylogenetic perspective across the Apicomplexa.

DOI10.4161/cib.3.1.9794
Alternate JournalCommun Integr Biol
PubMed ID20539776
PubMed Central IDPMC2881234
Grant ListR01 AI046675 / AI / NIAID NIH HHS / United States

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