Title | Antiretroviral drug-based microbicides to prevent HIV-1 sexual transmission. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Klasse PJohan, Shattock R, Moore JP |
Journal | Annu Rev Med |
Volume | 59 |
Pagination | 455-71 |
Date Published | 2008 |
ISSN | 0066-4219 |
Keywords | Anti-Retroviral Agents, Female, HIV Infections, HIV-1, Humans, Male, Vaginal Creams, Foams, and Jellies |
Abstract | The development of a vaginal (and perhaps a rectal) microbicide would be of major benefit for slowing the global spread of human immunodeficiency virus type 1 (HIV-1). A microbicide is a gel or related device that, when inserted vaginally or rectally, acts to prevent infection of a woman or a man by HIV-1 during sexual intercourse. A practical microbicide must be not only effective, safe, and user-friendly but also economically affordable in the developing world. To date, the performance of microbicide candidates in efficacy trials has been disappointing, but next-generation concepts now in or approaching clinical trials offer improved prospects for efficacy. The most plausible approaches involve topical application of antiretroviral agents with specific activity against HIV-1, compounds similar to drugs used to treat HIV-1 infection. How these inhibitors are applied may also be critical, with sustained-release formulations and vaginal ring delivery systems now becoming a high priority. |
DOI | 10.1146/annurev.med.59.061206.112737 |
Alternate Journal | Annu. Rev. Med. |
PubMed ID | 17892435 |
Grant List | U19 AI 65413 / AI / NIAID NIH HHS / United States |
Submitted by mam2155 on March 24, 2014 - 4:19pm