|Title||Antigenic variation by protozoan parasites: insights from Babesia bovis.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Dzikowski R, Deitsch K|
|Date Published||2006 Jan|
|Keywords||Animals, Antigenic Variation, Antigens, Protozoan, Babesia bovis, Cattle, Genes, Protozoan|
Antigenic variation of surface membrane proteins by protozoan parasites enables these pathogenic organisms to avoid host immune responses and thus perpetuate long-term infections. Babesia bovis, the causative agent of severe babesiosis in cattle, was previously shown to undergo antigenic variation through modifications to its primary surface antigen, a protein called VESA1. In this issue, Al-Khedery and Allred provide a detailed description of the genes that encode VESA1 and present convincing evidence for progressive, segmental gene conversion in the generation of variant forms of this surface antigen.
|Alternate Journal||Mol Microbiol|