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Antigenic variation by protozoan parasites: insights from Babesia bovis.

TitleAntigenic variation by protozoan parasites: insights from Babesia bovis.
Publication TypeJournal Article
Year of Publication2006
AuthorsDzikowski R, Deitsch K
JournalMol Microbiol
Volume59
Issue2
Pagination364-6
Date Published2006 Jan
ISSN0950-382X
KeywordsAnimals, Antigenic Variation, Antigens, Protozoan, Babesia bovis, Cattle, Genes, Protozoan
Abstract

Antigenic variation of surface membrane proteins by protozoan parasites enables these pathogenic organisms to avoid host immune responses and thus perpetuate long-term infections. Babesia bovis, the causative agent of severe babesiosis in cattle, was previously shown to undergo antigenic variation through modifications to its primary surface antigen, a protein called VESA1. In this issue, Al-Khedery and Allred provide a detailed description of the genes that encode VESA1 and present convincing evidence for progressive, segmental gene conversion in the generation of variant forms of this surface antigen.

DOI10.1111/j.1365-2958.2005.05007.x
Alternate JournalMol Microbiol
PubMed ID16390434

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