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Activity of Epigenetic Inhibitors against Plasmodium falciparum Asexual and Sexual Blood Stages.

TitleActivity of Epigenetic Inhibitors against Plasmodium falciparum Asexual and Sexual Blood Stages.
Publication TypeJournal Article
Year of Publication2020
AuthorsVanheer LN, Zhang H, Lin G, Kafsack BFC
JournalAntimicrob Agents Chemother
Volume64
Issue7
Date Published2020 06 23
ISSN1098-6596
Abstract

Earlier genetic and inhibitor studies showed that epigenetic regulation of gene expression is critical for malaria parasite survival in multiple life stages and a promising target for new antimalarials. We therefore evaluated the activity of 350 diverse epigenetic inhibitors against multiple stages of We observed ≥90% inhibition at 10 μM for 28% of compounds against asexual blood stages and early gametocytes, of which a third retained ≥90% inhibition at 1 μM.

DOI10.1128/AAC.02523-19
Alternate JournalAntimicrob Agents Chemother
PubMed ID32366713
PubMed Central IDPMC7318029
Grant ListR01 AI138499 / AI / NIAID NIH HHS / United States
R01 AI141965 / AI / NIAID NIH HHS / United States
R01 AI143714 / AI / NIAID NIH HHS / United States

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