Submitted by wcm_microbiolog... on October 13, 2020 - 1:43pm
Title | Activity of Epigenetic Inhibitors against Plasmodium falciparum Asexual and Sexual Blood Stages. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Vanheer LN, Zhang H, Lin G, Kafsack BFC |
Journal | Antimicrob Agents Chemother |
Volume | 64 |
Issue | 7 |
Date Published | 2020 06 23 |
ISSN | 1098-6596 |
Abstract | Earlier genetic and inhibitor studies showed that epigenetic regulation of gene expression is critical for malaria parasite survival in multiple life stages and a promising target for new antimalarials. We therefore evaluated the activity of 350 diverse epigenetic inhibitors against multiple stages of We observed ≥90% inhibition at 10 μM for 28% of compounds against asexual blood stages and early gametocytes, of which a third retained ≥90% inhibition at 1 μM. |
DOI | 10.1128/AAC.02523-19 |
Alternate Journal | Antimicrob Agents Chemother |
PubMed ID | 32366713 |
PubMed Central ID | PMC7318029 |
Grant List | R01 AI138499 / AI / NIAID NIH HHS / United States R01 AI141965 / AI / NIAID NIH HHS / United States R01 AI143714 / AI / NIAID NIH HHS / United States |