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Genome-wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor-associated signatures.

TitleGenome-wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor-associated signatures.
Publication TypeJournal Article
Year of Publication2006
AuthorsKathpalia VP, Mussak EN, Chow SS, Lam PH, Skelley N, Time M, Markelewicz RJ, Kanduc D, Lomas L, Xiang Z, Sinha AA
JournalJ Dermatol
Volume33
Issue5
Pagination309-18
Date Published2006 May
ISSN0385-2407
KeywordsAged, Aged, 80 and over, Carcinoma, Squamous Cell, Case-Control Studies, Cell Transformation, Neoplastic, DNA, Complementary, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, Genome, Human, Humans, Male, Reverse Transcriptase Polymerase Chain Reaction, RNA, Skin Neoplasms, Transcription, Genetic
Abstract

The elucidation of specific genetic changes associated with human cancer pathogenesis has focused efforts to relate such changes to the neoplastic phenotype. To further our understanding of the genetic basis of human squamous cell carcinoma (SCC) of the skin, this study used a genome-wide (12 627 sequences) approach to determine transcriptional signatures in lesional and nonlesional sites from five SCC patients. Several novel genes involving the p53 pathway, anti-apoptotic pathways, signal transduction, structural loss and DNA replication, including BCL2A1, MUC4, PTPN11 (SHP2) and FGF9, are upregulated in SCC and could warrant further study regarding their role in disease pathogenesis. SCC pathology is likely combinatorial in nature involving the compounded changes from several cellular processes.

DOI10.1111/j.1346-8138.2006.00075.x
Alternate JournalJ. Dermatol.
PubMed ID16700662

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