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Aldrich, Courtney C
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Tiwari D
,
Park SWoong
,
Essawy MM
,
Dawadi S
,
Mason A
,
Nandakumar M
,
Zimmerman M
,
Mina M
,
Ho HPin
,
Engelhart CA
et al.
. 2018.
Targeting protein biotinylation enhances tuberculosis chemotherapy.
.
Sci Transl Med. 10(438)
Bockman MR
,
Kalinda AS
,
Petrelli R
,
De la Mora-Rey T
,
Tiwari D
,
Liu F
,
Dawadi S
,
Nandakumar M
,
Rhee KY
,
Schnappinger D
et al.
. 2015.
Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
.
J Med Chem. 58(18):7349-7369.
Park SWoong
,
Casalena DE
,
Wilson DJ
,
Dai R
,
Nag PP
,
Liu F
,
Boyce JP
,
Bittker JA
,
Schreiber SL
,
Finzel BC
et al.
. 2015.
Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.
.
Chem Biol. 22(1):76-86.
S
Liu F
,
Dawadi S
,
Maize KM
,
Dai R
,
Park SWoong
,
Schnappinger D
,
Finzel BC
,
Aldrich CC
. 2017.
Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.
.
J Med Chem. 60(13):5507-5520.
M
Shi C
,
Geders TW
,
Park SWoong
,
Wilson DJ
,
Boshoff HI
,
Abayomi O
,
Barry CE
,
Schnappinger D
,
Finzel BC
,
Aldrich CC
. 2011.
Mechanism-based inactivation by aromatization of the transaminase BioA involved in biotin biosynthesis in Mycobaterium tuberculosis.
.
J Am Chem Soc. 133(45):18194-201.
G
Kim J-H
,
O'Brien KM
,
Sharma R
,
Boshoff HIM
,
Rehren G
,
Chakraborty S
,
Wallach JB
,
Monteleone M
,
Wilson DJ
,
Aldrich CC
et al.
. 2013.
A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.
.
Proc Natl Acad Sci U S A. 110(47):19095-100.
F
Dai R
,
Geders TW
,
Liu F
,
Park SWoong
,
Schnappinger D
,
Aldrich CC
,
Finzel BC
. 2015.
Fragment-based exploration of binding site flexibility in Mycobacterium tuberculosis BioA.
.
J Med Chem. 58(13):5208-17.
E
Park SWoong
,
Klotzsche M
,
Wilson DJ
,
Boshoff HI
,
Eoh H
,
Manjunatha U
,
Blumenthal A
,
Rhee K
,
Barry CE
,
Aldrich CC
et al.
. 2011.
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.
.
PLoS Pathog. 7(9):e1002264.
B
Shi C
,
Tiwari D
,
Wilson DJ
,
Seiler CL
,
Schnappinger D
,
Aldrich CC
. 2013.
Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation.
.
ACS Med Chem Lett. 4(12)
Duckworth BP
,
Geders TW
,
Tiwari D
,
Boshoff HI
,
Sibbald PA
,
Barry CE
,
Schnappinger D
,
Finzel BC
,
Aldrich CC
. 2011.
Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis.
.
Chem Biol. 18(11):1432-41.