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Found 16 results
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Rhee, Kyu Y
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T
Trujillo C
,
Blumenthal A
,
Marrero J
,
Rhee KY
,
Schnappinger D
,
Ehrt S
. 2014.
Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection.
.
mBio. 5(2):e00085.
Bockman MR
,
Kalinda AS
,
Petrelli R
,
De la Mora-Rey T
,
Tiwari D
,
Liu F
,
Dawadi S
,
Nandakumar M
,
Rhee KY
,
Schnappinger D
et al.
. 2015.
Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
.
J Med Chem. 58(18):7349-7369.
N
Warrier T
,
Kapilashrami K
,
Argyrou A
,
Ioerger TR
,
Little D
,
Murphy KC
,
Nandakumar M
,
Park S
,
Gold B
,
Mi J
et al.
. 2016.
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
.
Proc Natl Acad Sci U S A. 113(31):E4523-30.
de Carvalho LPedro S
,
Darby CM
,
Rhee KY
,
Nathan C
. 2011.
Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis.
.
ACS Med Chem Lett. 2(11):849-854.
M
de Carvalho LPedro S
,
Fischer SM
,
Marrero J
,
Nathan C
,
Ehrt S
,
Rhee KY
. 2010.
Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.
.
Chem Biol. 17(10):1122-31.
Ehrt S
,
Schnappinger D
,
Rhee KY
. 2018.
Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.
.
Nat Rev Microbiol. 16(8):496-507.
I
Negri A
,
Javidnia P
,
Mu R
,
Zhang X
,
Vendome J
,
Gold B
,
Roberts J
,
Barman D
,
Ioerger T
,
Sacchettini JC
et al.
. 2018.
Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.
.
ACS Infect Dis. 4(5):771-787.
G
Puckett S
,
Trujillo C
,
Wang Z
,
Eoh H
,
Ioerger TR
,
Krieger I
,
Sacchettini J
,
Schnappinger D
,
Rhee KY
,
Ehrt S
. 2017.
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.
.
Proc Natl Acad Sci U S A. 114(11):E2225-E2232.
Marrero J
,
Trujillo C
,
Rhee KY
,
Ehrt S
. 2013.
Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.
.
PLoS Pathog. 9(1):e1003116.
Marrero J
,
Rhee KY
,
Schnappinger D
,
Pethe K
,
Ehrt S
. 2010.
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection.
.
Proc Natl Acad Sci U S A. 107(21):9819-24.
Kim J-H
,
O'Brien KM
,
Sharma R
,
Boshoff HIM
,
Rehren G
,
Chakraborty S
,
Wallach JB
,
Monteleone M
,
Wilson DJ
,
Aldrich CC
et al.
. 2013.
A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.
.
Proc Natl Acad Sci U S A. 110(47):19095-100.
F
Ruecker N
,
Jansen R
,
Trujillo C
,
Puckett S
,
Jayachandran P
,
Piroli GG
,
Frizzell N
,
Molina H
,
Rhee KY
,
Ehrt S
. 2017.
Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.
.
Cell Chem Biol. 24(3):306-315.
E
Maksymiuk C
,
Balakrishnan A
,
Bryk R
,
Rhee KY
,
Nathan C
. 2015.
E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.
.
Proc Natl Acad Sci U S A. 112(43):E5834-43.
D
Zaveri A
,
Wang R
,
Botella L
,
Sharma R
,
Zhu L
,
Wallach JB
,
Song N
,
Jansen RS
,
Rhee KY
,
Ehrt S
et al.
. 2020.
Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.
.
Mol Microbiol.
Wei J-R
,
Krishnamoorthy V
,
Murphy K
,
Kim J-H
,
Schnappinger D
,
Alber T
,
Sassetti CM
,
Rhee KY
,
Rubin EJ
. 2011.
Depletion of antibiotic targets has widely varying effects on growth.
.
Proc Natl Acad Sci U S A. 108(10):4176-81.
C
Rhee KY
,
de Carvalho LPedro Sori
,
Bryk R
,
Ehrt S
,
Marrero J
,
Park SWoong
,
Schnappinger D
,
Venugopal A
,
Nathan C
. 2011.
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.
.
Trends Microbiol. 19(7):307-14.