Microbiology and Immunology

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Found 85 results

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2015

Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LPedro Sori, Rhee K, Ehrt S. 2015. Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.. Nat Commun. 6:7912.

2014

Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt S. 2014. Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.. PLoS Pathog. 10(5):e1004144.

Gaur RL, Ren K, Blumenthal A, Bhamidi S, González-Nilo FD, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD et al.. 2014. LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.. PLoS Pathog. 10(9):e1004376.

Danilchanka O, Sun J, Pavlenok M, Maueröder C, Speer A, Siroy A, Marrero J, Trujillo C, Mayhew DL, Doornbos KS et al.. 2014. An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity.. Proc Natl Acad Sci U S A. 111(18):6750-5.

Schnappinger D, Ehrt S. 2014. Regulated Expression Systems for Mycobacteria and Their Applications.. Microbiol Spectr. 2(1):MGM2-0018-2013.

Schnappinger D, Ehrt S. 2014. Regulated Expression Systems for Mycobacteria and Their Applications.. Microbiol Spectr. 2(1)

Trujillo C, Blumenthal A, Marrero J, Rhee KY, Schnappinger D, Ehrt S. 2014. Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection.. mBio. 5(2):e00085.

2013

Kim J-H, O'Brien KM, Sharma R, Boshoff HIM, Rehren G, Chakraborty S, Wallach JB, Monteleone M, Wilson DJ, Aldrich CC et al.. 2013. A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.. Proc Natl Acad Sci U S A. 110(47):19095-100.

Marrero J, Trujillo C, Rhee KY, Ehrt S. 2013. Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.. PLoS Pathog. 9(1):e1003116.

Sakamoto K, Kim MJeong, Rhoades ER, Allavena RE, Ehrt S, Wainwright HC, Russell DG, Rohde KH. 2013. Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases.. Infect Immun. 81(3):764-76.

Ehrt S, Rhee K. 2013. Mycobacterium tuberculosis metabolism and host interaction: mysteries and paradoxes.. Curr Top Microbiol Immunol. 374:163-88.

Small JL, Park SWoong, Kana BD, Ioerger TR, Sacchettini JC, Ehrt S. 2013. Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis.. mBio. 4(5):e00475-13.

Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S. 2013. Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis.. J Biol Chem. 288(18):12489-99.

Darby CM, Ingólfsson HI, Jiang X, Shen C, Sun M, Zhao N, Burns K, Liu G, Ehrt S, J Warren D et al.. 2013. Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis.. PLoS One. 8(7):e68942.

2012

Robertson BD, Altmann D, Barry C, Bishai B, Cole S, Dick T, Duncan K, Dye C, Ehrt S, Esmail H et al.. 2012. Detection and treatment of subclinical tuberculosis.. Tuberculosis (Edinb). 92(6):447-52.

Blumenthal A, Nagalingam G, Huch JH, Walker L, Guillemin GJ, Smythe GA, Ehrt S, Britton WJ, Saunders BM. 2012. M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.. PLoS One. 7(5):e37314.

2011

Rhee KY, de Carvalho LPedro Sori, Bryk R, Ehrt S, Marrero J, Park SWoong, Schnappinger D, Venugopal A, Nathan C. 2011. Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.. Trends Microbiol. 19(7):307-14.

Park SWoong, Klotzsche M, Wilson DJ, Boshoff HI, Eoh H, Manjunatha U, Blumenthal A, Rhee K, Barry CE, Aldrich CC et al.. 2011. Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.. PLoS Pathog. 7(9):e1002264.

Santangelo Mde la Paz, Gest PM, Guerin ME, Coinçon M, Pham H, Ryan G, Puckett SE, Spencer JS, Gonzalez-Juarrero M, Daher R et al.. 2011. Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.. J Biol Chem. 286(46):40219-31.

Darby CM, Venugopal A, Ehrt S, Nathan CF. 2011. Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice.. Tuberculosis (Edinb). 91(5):343-7.

Koo M-S, Manca C, Yang G, O'Brien P, Sung N, Tsenova L, Subbian S, Fallows D, Muller G, Ehrt S et al.. 2011. Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice.. PLoS One. 6(2):e17091.

Venugopal A, Bryk R, Shi S, Rhee K, Rath P, Schnappinger D, Ehrt S, Nathan C. 2011. Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.. Cell Host Microbe. 9(1):21-31.

2010

Marrero J, Rhee KY, Schnappinger D, Pethe K, Ehrt S. 2010. Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection.. Proc Natl Acad Sci U S A. 107(21):9819-24.

Seimon TA, Kim M-J, Blumenthal A, Koo J, Ehrt S, Wainwright H, Bekker L-G, Kaplan G, Nathan C, Tabas I et al.. 2010. Induction of ER stress in macrophages of tuberculosis granulomas.. PLoS One. 5(9):e12772.

de Carvalho LPedro S, Fischer SM, Marrero J, Nathan C, Ehrt S, Rhee KY. 2010. Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.. Chem Biol. 17(10):1122-31.