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Found 58 results
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2019
Johnson EO
,
LaVerriere E
,
Office E
,
Stanley M
,
Meyer E
,
Kawate T
,
Gomez JE
,
Audette RE
,
Bandyopadhyay N
,
Betancourt N
et al.
. 2019.
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.
.
Nature. 571(7763):72-78.
Ballinger E
,
Mosior J
,
Hartman T
,
Burns-Huang K
,
Gold B
,
Morris R
,
Goullieux L
,
Blanc I
,
Vaubourgeix J
,
Lagrange S
et al.
. 2019.
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.
.
Science. 363(6426)
Zhan W
,
Hsu H-C
,
Morgan T
,
Ouellette T
,
Burns-Huang K
,
Hara R
,
Wright AG
,
Imaeda T
,
Okamoto R
,
Sato K
et al.
. 2019.
Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome.
.
J Med Chem. 62(20):9246-9253.
Subramaniyam S
,
DeJesus MA
,
Zaveri A
,
Smith CM
,
Baker RE
,
Ehrt S
,
Schnappinger D
,
Sassetti CM
,
Ioerger TR
. 2019.
Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression.
.
BMC Bioinformatics. 20(1):603.
2018
Kirkman LA
,
Zhan W
,
Visone J
,
Dziedziech A
,
Singh PK
,
Fan H
,
Tong X
,
Bruzual I
,
Hara R
,
Kawasaki M
et al.
. 2018.
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
.
Proc Natl Acad Sci U S A. 115(29):E6863-E6870.
Negri A
,
Javidnia P
,
Mu R
,
Zhang X
,
Vendome J
,
Gold B
,
Roberts J
,
Barman D
,
Ioerger T
,
Sacchettini JC
et al.
. 2018.
Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.
.
ACS Infect Dis. 4(5):771-787.
Tiwari D
,
Park SWoong
,
Essawy MM
,
Dawadi S
,
Mason A
,
Nandakumar M
,
Zimmerman M
,
Mina M
,
Ho HPin
,
Engelhart CA
et al.
. 2018.
Targeting protein biotinylation enhances tuberculosis chemotherapy.
.
Sci Transl Med. 10(438)
2017
Xu W
,
DeJesus MA
,
Rücker N
,
Engelhart CA
,
Wright MG
,
Healy C
,
Lin K
,
Wang R
,
Park SWoong
,
Ioerger TR
et al.
. 2017.
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
.
Antimicrob Agents Chemother. 61(12)
Puckett S
,
Trujillo C
,
Wang Z
,
Eoh H
,
Ioerger TR
,
Krieger I
,
Sacchettini J
,
Schnappinger D
,
Rhee KY
,
Ehrt S
. 2017.
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.
.
Proc Natl Acad Sci U S A. 114(11):E2225-E2232.
2016
Warrier T
,
Kapilashrami K
,
Argyrou A
,
Ioerger TR
,
Little D
,
Murphy KC
,
Nandakumar M
,
Park S
,
Gold B
,
Mi J
et al.
. 2016.
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.
.
Proc Natl Acad Sci U S A. 113(31):E4523-30.
Van Voorhis WC
,
Adams JH
,
Adelfio R
,
Ahyong V
,
Akabas MH
,
Alano P
,
Alday A
,
Resto YAlemán
,
Alsibaee A
,
Alzualde A
et al.
. 2016.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
.
PLoS Pathog. 12(7):e1005763.
Van Voorhis WC
,
Adams JH
,
Adelfio R
,
Ahyong V
,
Akabas MH
,
Alano P
,
Alday A
,
Resto YAlemán
,
Alsibaee A
,
Alzualde A
et al.
. 2016.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
.
PLoS Pathog. 12(7):e1005763.
Van Voorhis WC
,
Adams JH
,
Adelfio R
,
Ahyong V
,
Akabas MH
,
Alano P
,
Alday A
,
Resto YAlemán
,
Alsibaee A
,
Alzualde A
et al.
. 2016.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
.
PLoS Pathog. 12(7):e1005763.
Korte J
,
Alber M
,
Trujillo CM
,
Syson K
,
Koliwer-Brandl H
,
Deenen R
,
Köhrer K
,
DeJesus MA
,
Hartman T
,
Jacobs WR
et al.
. 2016.
Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.
.
PLoS Pathog. 12(12):e1006043.
2015
Frykman PK
,
Nordenskjöld A
,
Kawaguchi A
,
Hui TT
,
Granström AL
,
Cheng Z
,
Tang J
,
Underhill DM
,
Iliev ID
,
Funari VA
et al.
. 2015.
Characterization of Bacterial and Fungal Microbiome in Children with Hirschsprung Disease with and without a History of Enterocolitis: A Multicenter Study.
.
PLoS One. 10(4):e0124172.
Iliev ID
. 2015.
Dectin-1 Exerts Dual Control in the Gut.
.
Cell Host Microbe. 18(2):139-41.
Seehus CR
,
Aliahmad P
,
de la Torre B
,
Iliev ID
,
Spurka L
,
Funari VA
,
Kaye J
. 2015.
The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor.
.
Nat Immunol. 16(6):599-608.
Sanders RW
,
van Gils MJ
,
Derking R
,
Sok D
,
Ketas TJ
,
Burger JA
,
Ozorowski G
,
Cupo A
,
Simonich C
,
Goo L
et al.
. 2015.
HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers.
.
Science. 349(6244):aac4223.
Tang J
,
Iliev ID
,
Brown J
,
Underhill DM
,
Funari VA
. 2015.
Mycobiome: Approaches to analysis of intestinal fungi.
.
J Immunol Methods. 421:112-21.
Müller S
,
Wolf AJ
,
Iliev ID
,
Berg BL
,
Underhill DM
,
Liu GY
. 2015.
Poorly Cross-Linked Peptidoglycan in MRSA Due to mecA Induction Activates the Inflammasome and Exacerbates Immunopathology.
.
Cell Host Microbe. 18(5):604-12.
2014
Underhill DM
,
Iliev ID
. 2014.
The mycobiota: interactions between commensal fungi and the host immune system.
.
Nat Rev Immunol. 14(6):405-16.
2013
Small JL
,
Park SWoong
,
Kana BD
,
Ioerger TR
,
Sacchettini JC
,
Ehrt S
. 2013.
Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis.
.
mBio. 4(5):e00475-13.
Iliev ID
,
Underhill DM
. 2013.
Striking a balance: fungal commensalism versus pathogenesis.
.
Curr Opin Microbiol. 16(3):366-73.
Darby CM
,
Ingólfsson HI
,
Jiang X
,
Shen C
,
Sun M
,
Zhao N
,
Burns K
,
Liu G
,
Ehrt S
,
J Warren D
et al.
. 2013.
Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis.
.
PLoS One. 8(7):e68942.
2012
Spadoni I
,
Iliev ID
,
Rossi G
,
Rescigno M
. 2012.
Dendritic cells produce TSLP that limits the differentiation of Th17 cells, fosters Treg development, and protects against colitis.
.
Mucosal Immunol. 5(2):184-93.
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