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Found 162 results
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2017
Ruecker N
,
Jansen R
,
Trujillo C
,
Puckett S
,
Jayachandran P
,
Piroli GG
,
Frizzell N
,
Molina H
,
Rhee KY
,
Ehrt S
. 2017.
Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.
.
Cell Chem Biol. 24(3):306-315.
Puckett S
,
Trujillo C
,
Wang Z
,
Eoh H
,
Ioerger TR
,
Krieger I
,
Sacchettini J
,
Schnappinger D
,
Rhee KY
,
Ehrt S
. 2017.
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.
.
Proc Natl Acad Sci U S A. 114(11):E2225-E2232.
Puckett S
,
Trujillo C
,
Wang Z
,
Eoh H
,
Ioerger TR
,
Krieger I
,
Sacchettini J
,
Schnappinger D
,
Rhee KY
,
Ehrt S
. 2017.
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.
.
Proc Natl Acad Sci U S A. 114(11):E2225-E2232.
Botella H
,
Vaubourgeix J
,
Lee MHee
,
Song N
,
Xu W
,
Makinoshima H
,
Glickman MS
,
Ehrt S
. 2017.
Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress.
.
EMBO J. 36(4):536-548.
Poran A
,
Nötzel C
,
Aly O
,
Mencia-Trinchant N
,
Harris CT
,
Guzman ML
,
Hassane DC
,
Elemento O
,
Kafsack BFC
. 2017.
Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites.
.
Nature. 551(7678):95-99.
2016
Schnappinger D
,
Ehrt S
. 2016.
A broader spectrum of tuberculosis.
.
Nat Med. 22(10):1076-1077.
Zeng H
,
Guo M
,
Zhou T
,
Tan L
,
Chong CNok
,
Zhang T
,
Dong X
,
Xiang JZhaoying
,
Yu AS
,
Yue L
et al.
. 2016.
An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery.
.
Cell Stem Cell. 19(3):326-40.
Lin K
,
O'Brien KM
,
Trujillo C
,
Wang R
,
Wallach JB
,
Schnappinger D
,
Ehrt S
. 2016.
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.
.
PLoS Pathog. 12(6):e1005675.
Van Voorhis WC
,
Adams JH
,
Adelfio R
,
Ahyong V
,
Akabas MH
,
Alano P
,
Alday A
,
Resto YAlemán
,
Alsibaee A
,
Alzualde A
et al.
. 2016.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
.
PLoS Pathog. 12(7):e1005763.
Korte J
,
Alber M
,
Trujillo CM
,
Syson K
,
Koliwer-Brandl H
,
Deenen R
,
Köhrer K
,
DeJesus MA
,
Hartman T
,
Jacobs WR
et al.
. 2016.
Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.
.
PLoS Pathog. 12(12):e1006043.
2015
Schnappinger D
,
O'Brien KM
,
Ehrt S
. 2015.
Construction of conditional knockdown mutants in mycobacteria.
.
Methods Mol Biol. 1285:151-75.
Goodsmith N
,
Guo XV
,
Vandal OH
,
Vaubourgeix J
,
Wang R
,
Botella H
,
Song S
,
Bhatt K
,
Liba A
,
Salgame P
et al.
. 2015.
Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.
.
PLoS Pathog. 11(2):e1004645.
Zhao N
,
Sun M
,
Burns-Huang K
,
Jiang X
,
Ling Y
,
Darby C
,
Ehrt S
,
Liu G
,
Nathan C
. 2015.
Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis.
.
PLoS One. 10(5):e0126211.
Ehrt S
,
Rhee K
,
Schnappinger D
. 2015.
Mycobacterial genes essential for the pathogen's survival in the host.
.
Immunol Rev. 264(1):319-26.
Zhao N
,
Darby CM
,
Small J
,
Bachovchin DA
,
Jiang X
,
Burns-Huang KE
,
Botella H
,
Ehrt S
,
Boger DL
,
Anderson ED
et al.
. 2015.
Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.
.
ACS Chem Biol. 10(2):364-71.
Zhao N
,
Darby CM
,
Small J
,
Bachovchin DA
,
Jiang X
,
Burns-Huang KE
,
Botella H
,
Ehrt S
,
Boger DL
,
Anderson ED
et al.
. 2015.
Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.
.
ACS Chem Biol. 10(2):364-71.
Ganapathy U
,
Marrero J
,
Calhoun S
,
Eoh H
,
de Carvalho LPedro Sori
,
Rhee K
,
Ehrt S
. 2015.
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.
.
Nat Commun. 6:7912.
Ganapathy U
,
Marrero J
,
Calhoun S
,
Eoh H
,
de Carvalho LPedro Sori
,
Rhee K
,
Ehrt S
. 2015.
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.
.
Nat Commun. 6:7912.
2014
Puckett S
,
Trujillo C
,
Eoh H
,
Marrero J
,
Spencer J
,
Jackson M
,
Schnappinger D
,
Rhee K
,
Ehrt S
. 2014.
Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.
.
PLoS Pathog. 10(5):e1004144.
Puckett S
,
Trujillo C
,
Eoh H
,
Marrero J
,
Spencer J
,
Jackson M
,
Schnappinger D
,
Rhee K
,
Ehrt S
. 2014.
Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.
.
PLoS Pathog. 10(5):e1004144.
Gaur RL
,
Ren K
,
Blumenthal A
,
Bhamidi S
,
González-Nilo FD
,
Gibbs S
,
Jackson M
,
Zare RN
,
Ehrt S
,
Ernst JD
et al.
. 2014.
LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.
.
PLoS Pathog. 10(9):e1004376.
Gaur RL
,
Ren K
,
Blumenthal A
,
Bhamidi S
,
González-Nilo FD
,
Gibbs S
,
Jackson M
,
Zare RN
,
Ehrt S
,
Ernst JD
et al.
. 2014.
LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.
.
PLoS Pathog. 10(9):e1004376.
Danilchanka O
,
Sun J
,
Pavlenok M
,
Maueröder C
,
Speer A
,
Siroy A
,
Marrero J
,
Trujillo C
,
Mayhew DL
,
Doornbos KS
et al.
. 2014.
An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity.
.
Proc Natl Acad Sci U S A. 111(18):6750-5.
Schnappinger D
,
Ehrt S
. 2014.
Regulated Expression Systems for Mycobacteria and Their Applications.
.
Microbiol Spectr. 2(1):MGM2-0018-2013.
Schnappinger D
,
Ehrt S
. 2014.
Regulated Expression Systems for Mycobacteria and Their Applications.
.
Microbiol Spectr. 2(1)
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